摘要
汞和一甲基汞中毒因为几个方面的原因得到重视。与其它金属一样,螯合疗法被证明是汞中毒病人最有效的治疗方式。通过确切的知道金属吸收、在不同组织内部和组织间的转运、以及(可能的)清除的所有的生理机制,能够有效的增强治疗效果和减少副作用。然而,所有这些方面,严格的依赖于金属和螯合剂所处系统的化学形态(如给定系统中某组分的化学形态分布)。鉴于此,这个综述分析了运用于汞和一甲基汞在化学形态领域中的研究方法。对它们只要的来源一个简明的总结后,对汞中毒治疗的生理模式也进行了探讨。通过模拟出现在生物流体、或经常被用于螯合疗法的主要配体种类的行为,对不同的汞螯合剂的结合能力进行了分析。它们的螯合能力通过半经验参数法进行深入评估,这种评估方法已经被认为是螯合能力的客观量化方法,也是高效螯合剂的主要特征的评估基础。
关键词: 螯合疗法,经验关系,配体,金属复合物,螯合能力,形态
Current Medicinal Chemistry
Title:Chelating Agents for the Sequestration of Mercury(II) and Monomethyl Mercury(II)
Volume: 21 Issue: 33
Author(s): Francesco Crea, Concetta De Stefano, Claudia Foti, Demetrio Milea and Silvio Sammartano
Affiliation:
关键词: 螯合疗法,经验关系,配体,金属复合物,螯合能力,形态
摘要: Both mercury(II) and monomethyl mercury(II) poisonings are of great concern for several reasons. As it happens for other metals, chelation therapy is the most indicated treatment for poisoned patients. The efficacy of the therapy and the reduction of side-effects can be sensibly enhanced by an accurate knowledge of all the physiological mechanisms involved in metal uptake, transport within and between various tissues, and (possibly) clearance. All these aspects, however, are strictly dependent on the chemical speciation (i.e., the distribution of the chemical species of a component in a given system) of both the metal and the chelating agent in the systems where they are present. In this light, this review analyzes the state of the art of research performed in this field for mercury(II) and methylmercury(II). After a brief summary of their main sources, the physiological patterns for the treatment of mercury poisoning have also been considered. The binding ability of various chelating agents toward mercury has been then analyzed by modeling the behavior of the main classes of ligands present in biological fluids and/or frequently used in chelation therapy. Their sequestering ability has been successively evaluated by means of a semiempirical parameter already proposed for its objective quantification, and the main characteristics of an efficient chelating agent have been evaluated on this basis.
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Crea Francesco, Stefano De Concetta, Foti Claudia, Milea Demetrio and Sammartano Silvio, Chelating Agents for the Sequestration of Mercury(II) and Monomethyl Mercury(II), Current Medicinal Chemistry 2014; 21 (33) . https://dx.doi.org/10.2174/0929867321666140601160740
DOI https://dx.doi.org/10.2174/0929867321666140601160740 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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