Abstract
Classic chemotherapy has little or no specificity for cancer cells, normally resulting in low accumulation at the tumor region (inefficacy), and in severe side effects (toxicity). This challenge has resulted in the development of several delivery strategies for chemotherapy agents to improve their concentration at the tumor site, simultaneously increasing their anticancer efficacy, while reducing the associated adverse systemic effects. In this work, the potential of drug delivery strategies involving the use of nanocarriers for controlling the biodistribution of antitumor drugs is deeply revised: passive targeting (through the enhanced permeability and retention effect, EPR effect) and active targeting (including stimuli-sensitive carriers and ligand-mediated delivery). Special attention will be also focussed on the recent approaches for overcoming multi-drug resistance. Finally, a general view of the problem of “nanotoxicity” in cancer treatment is also given.
Keywords: Active targeting, antitumor activity, cancer treatment, chemotherapy agent, colloidal drug delivery systems, controlled release, drug carrier, nanotoxicity, passive targeting, 5-fluorouracil, multi-drug resistance, reticuloendothelial system, mononuclear phagocyte system, opsonins, Doxorubicin, DOX-SLNs, caprolactone, tamoxifen, PLA-PEG, asialoglycoprotein, HepG2, monoclonal antibodies, Pseudomonas, PE38KDEL, Flow cytometry, confocal microscopy, Peptide-Mediated Targeting, Inulin multi-methacrylate (IMMA), CREKA, fibronectin, DAOY, vasoactive intestinal peptide, Integrin-Mediated Targeting, H2009, Aptamer-Mediated Targeting, PSMA, LNCaP xenograft, Folate Receptor Targeting, HeLa, paclitaxel prodrug, Cremophor, prodrug therapy, TRAIL immunotherapy, Transferrin Receptor Targeting, fluorescence microscopic, EGFR, acute myeloid leukemia, hyperthermia, Thermo-sensitive magnetoliposomes, methotrexate, Magnetic Drug Targeting, Ultrasound-Mediated Drug Delivery, Low frequency ultrasound, metalloproteinase-2, PEGylation, paclitaxel, tariquidar, Myocet, Doxil, Caelyx, Genexol-PM
Mini-Reviews in Medicinal Chemistry
Title: Drug Targeting Strategies in Cancer Treatment: An Overview
Volume: 11 Issue: 1
Author(s): J. L. Arias
Affiliation:
Keywords: Active targeting, antitumor activity, cancer treatment, chemotherapy agent, colloidal drug delivery systems, controlled release, drug carrier, nanotoxicity, passive targeting, 5-fluorouracil, multi-drug resistance, reticuloendothelial system, mononuclear phagocyte system, opsonins, Doxorubicin, DOX-SLNs, caprolactone, tamoxifen, PLA-PEG, asialoglycoprotein, HepG2, monoclonal antibodies, Pseudomonas, PE38KDEL, Flow cytometry, confocal microscopy, Peptide-Mediated Targeting, Inulin multi-methacrylate (IMMA), CREKA, fibronectin, DAOY, vasoactive intestinal peptide, Integrin-Mediated Targeting, H2009, Aptamer-Mediated Targeting, PSMA, LNCaP xenograft, Folate Receptor Targeting, HeLa, paclitaxel prodrug, Cremophor, prodrug therapy, TRAIL immunotherapy, Transferrin Receptor Targeting, fluorescence microscopic, EGFR, acute myeloid leukemia, hyperthermia, Thermo-sensitive magnetoliposomes, methotrexate, Magnetic Drug Targeting, Ultrasound-Mediated Drug Delivery, Low frequency ultrasound, metalloproteinase-2, PEGylation, paclitaxel, tariquidar, Myocet, Doxil, Caelyx, Genexol-PM
Abstract: Classic chemotherapy has little or no specificity for cancer cells, normally resulting in low accumulation at the tumor region (inefficacy), and in severe side effects (toxicity). This challenge has resulted in the development of several delivery strategies for chemotherapy agents to improve their concentration at the tumor site, simultaneously increasing their anticancer efficacy, while reducing the associated adverse systemic effects. In this work, the potential of drug delivery strategies involving the use of nanocarriers for controlling the biodistribution of antitumor drugs is deeply revised: passive targeting (through the enhanced permeability and retention effect, EPR effect) and active targeting (including stimuli-sensitive carriers and ligand-mediated delivery). Special attention will be also focussed on the recent approaches for overcoming multi-drug resistance. Finally, a general view of the problem of “nanotoxicity” in cancer treatment is also given.
Export Options
About this article
Cite this article as:
L. Arias J., Drug Targeting Strategies in Cancer Treatment: An Overview, Mini-Reviews in Medicinal Chemistry 2011; 11 (1) . https://dx.doi.org/10.2174/138955711793564024
DOI https://dx.doi.org/10.2174/138955711793564024 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Synthetic and Application Perspectives of Azapodophyllotoxins: Alternative Scaffolds of Podophyllotoxin
Current Medicinal Chemistry Kaempferol-3-<i>O</i>-Rhamnoside Inhibits the Proliferation of Jurkat Cells Through Jun Amino-Terminal Kinase Signaling
The Natural Products Journal Clinical Impact of the Detection of BRAF Mutations in Thyroid Pathology: Potential Usefulness as Diagnostic, Prognostic and Theragnostic Applications
Current Medicinal Chemistry The Role of Chromogranin A (CgA) in Monitoring Patients with Prostate Cancer Under Androgen Deprivation Therapy: Comparison with Prostatic Specific Antigen (PSA)
Current Radiopharmaceuticals Retinoic Acid Metabolism and Mechanism of Action: A Review
Current Drug Metabolism Ultrasound Assisted-synthesis and Biological Evaluation of Piperazinylprop- 1-en-2-yloxy-2H-chromen-2-ones as Cytotoxic Agents
Letters in Drug Design & Discovery Galanthus nivalis Agglutinin (GNA)-Related Lectins: Traditional Proteins, Burgeoning Drugs?
Current Chemical Biology Synthesis, Characterization, Anticancer and Antibacterial Activity of Some Novel Pyrano[2,3-d]pyrimidinone Carbonitrile Derivatives
Anti-Cancer Agents in Medicinal Chemistry MicroRNA Levels in Cervical Cancer Samples and Relationship with Lesion Grade and HPV Infection
MicroRNA HPV Screening: Available Data and Recommendations for Clinical Practice
Current Cancer Therapy Reviews CD40L - A Multipotent Molecule for Tumor Therapy
Endocrine, Metabolic & Immune Disorders - Drug Targets Application of Molecular Imaging Technologies in Antitumor Drug Development and Therapy
Current Pharmaceutical Design Toxicological Profile of Therapeutic Nanodelivery Systems
Current Drug Metabolism Metallopharmaceuticals in Therapy - A New Horizon for Scientific Research
Current Medicinal Chemistry Tumour Hypoxia and Technetium Tracers: In Vivo Studies
Current Radiopharmaceuticals Recent Development in Indole Derivatives as Anticancer Agent: A Mechanistic Approach
Anti-Cancer Agents in Medicinal Chemistry Brain Tumor Causes, Symptoms, Diagnosis and Radiotherapy Treatment
Current Medical Imaging Cytotoxicity and Toxicological Studies of <i>Artocarpus altilis</i> Extracts, Inducing Apoptosis and Cell Cycle Arrest via <i>CASPASE-3</i> and <i>CASPASE-8</i> Pathways against Human Breast MCF-7 Cells
Combinatorial Chemistry & High Throughput Screening Paris Saponin VII Induces Apoptosis and Cell Cycle Arrest in Erythroleukemia Cells by a Mitochondrial Membrane Signaling Pathway
Anti-Cancer Agents in Medicinal Chemistry The Adjunctive Value of Diffusion Weighted Imaging in Diagnosis and Follow Up of Uterovaginal Diffuse B-cell Lymphoma: A Case Report and Literature Review
Current Medical Imaging