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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

NF-κB: The Inducible Factors of HIV-1 Transcription and their Inhibitors

Author(s): Yu Mingyan, Liu Xinyong and Erik De Clercq

Volume 9, Issue 1, 2009

Page: [60 - 69] Pages: 10

DOI: 10.2174/138955709787001677

Price: $65


NF-kappaB (NF-κB), the transcription factors of HIV-1, play an important role in triggering HIV transcription. The inhibition of NF-κB activation and their signaling pathway offers a potential anti-HIV therapy strategy. This review reports the mode of action of NF-κB in triggering HIV-1 transcription and the status of the inhibitors.

Keywords: AIDS, HIV-1, NF-κB, transcription, inhibitor, LTR, IκB, IKK

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