Abstract
Iron homeostasis disturbances are associated with liver disease. Non-alcoholic steatohepatitis is part of the spectrum of non-alcoholic fatty liver disease, which can progress to hepatic cirrhosis and end-stage liver disease. Increasing information supports that multiple factors underlie the development and progression of nonalcoholic steatohepatitis. However, the relation between non-alcoholic steatohepatitis and iron metabolism/ overload is still controversial. We review the recent literature, both basic and clinical, regarding iron homeostasis as it pertains to the pathogenesis of nonalcoholic fatty liver disease.
Keywords: Iron, iron overload, insulin resistance, metabolic syndrome, nonalcoholic fatty liver disease
Mini-Reviews in Medicinal Chemistry
Title: Importance of Iron and Iron Metabolism in Nonalcoholic Fatty Liver Disease
Volume: 8 Issue: 2
Author(s): Nahum Mendez-Sanchez, Hector Baptista-Gonzalez, Norberto C. Chavez-Tapia, Daniel Zamora-Valdes and Misael Uribe
Affiliation:
Keywords: Iron, iron overload, insulin resistance, metabolic syndrome, nonalcoholic fatty liver disease
Abstract: Iron homeostasis disturbances are associated with liver disease. Non-alcoholic steatohepatitis is part of the spectrum of non-alcoholic fatty liver disease, which can progress to hepatic cirrhosis and end-stage liver disease. Increasing information supports that multiple factors underlie the development and progression of nonalcoholic steatohepatitis. However, the relation between non-alcoholic steatohepatitis and iron metabolism/ overload is still controversial. We review the recent literature, both basic and clinical, regarding iron homeostasis as it pertains to the pathogenesis of nonalcoholic fatty liver disease.
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Cite this article as:
Mendez-Sanchez Nahum, Baptista-Gonzalez Hector, Chavez-Tapia C. Norberto, Zamora-Valdes Daniel and Uribe Misael, Importance of Iron and Iron Metabolism in Nonalcoholic Fatty Liver Disease, Mini-Reviews in Medicinal Chemistry 2008; 8 (2) . https://dx.doi.org/10.2174/138955708783498087
DOI https://dx.doi.org/10.2174/138955708783498087 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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