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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Advances in Characterization of Neuroprotective Peptide, Humanin

Author(s): T. Arakawa, A. Hirano, K. Shiraki, T. Niikura and Y. Kita

Volume 18, Issue 36, 2011

Page: [5554 - 5563] Pages: 10

DOI: 10.2174/092986711798347261

Price: $65


Humanin (HN), a short amino acid peptide, protects neurons as well as other cells from amyloid β-induced toxicities and other stresses. A number of HN binding proteins have been identified and their involvements in HN-mediated neuroprotection have been suggested in some cases. However, the way HN binds to the target molecules has never been clarified. Here we will review the structures of HN and HN analogs in solution as a function of solvent conditions and attempt to relate their structural characteristics to the functional properties.

Keywords: Humanin, neuroprotection, disordered structure, β-sheet, aggregation, liposome, amyloid, binding proteins, target molecules, Alzheimer's disease

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