Login Register Cart 0
Generic placeholder image

Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

The Dual Functions of Non-Coding RNA CRNDE in Different Tumors

Author(s): Zhuowei Wang, Yinxin Wu, Zhuoyin Du, Fangshun Tan, Yunxi Zhou, Zhicheng Zhang and Chengfu Yuan*

Volume 23, Issue 6, 2023

Published on: 03 October, 2022

Page: [719 - 733] Pages: 15

DOI: 10.2174/1389557522666220826124836

Price: $65

Abstract

Long non-coding RNA has attracted the interest of researchers as a relevant factor that can influence human cancers. As an oncogene and suppressor gene, it has numerous pathways and is closely related to the pathophysiology of human diseases. Meanwhile, it may become a novel treatment option and target for tumor treatment. CRNDE is the gene symbol for Colorectal Neoplasia Differentially Expressed (non-protein-coding) since it was found to be considerably higher in colorectal cancer when it was first discovered. It's transcribed from human chromosome 16. Many studies have shown that it is intimately linked to the etiology of many tumors and malignancies. According to the paper, the biological function and pathophysiological mechanism of CRNDE in tumors have been studied extensively in recent years. PubMed served as an essential platform for conducting literature searches and related analyses. CRNDE, a long non-coding RNA closely related to tumors, was highly expressed in many tumor cells. There were various underlying mechanisms affecting the progression of CRNDE-regulated tumorigenesis, including hepatocellular carcinoma, gastric cancer, prostate carcinoma, oral squamous cell carcinoma, breast cancer, thyroid cancer, myeloma, leukemia, melanoma, colorectal cancer, glioblastoma, osteosarcoma, cervical cancer, intrahepatic cholangiocarcinoma, nonsmall cell lung cancer, hepatoblastoma cell tumor, abdominal aortic aneurysm, nasopharyngeal carcinoma, bladder cancer, Wilms tumor, medulloblastoma, pancreatic cancer, gallbladder cancer, ovarian cancer, and renal cell carcinoma. CRNDE is involved in the processes of proliferation, migration, invasion, and inhibition of apoptosis of various cancer cells.

Keywords: Long non-coding RNA, CRNDE, tumorigenesis, potential therapeutic targets, cancer, biomarker.

« Previous Next »
Graphical Abstract

[1]
Zhang, J.; Yin, M.; Peng, G.; Zhao, Y. CRNDE: An important oncogenic long non-coding RNA in human cancers. Cell Prolif., 2018, 51(3), e12440.
[http://dx.doi.org/10.1111/cpr.12440] [PMID: 29405523]
[2]
Ellis, B.C.; Molloy, P.L.; Graham, L.D. CRNDE: A long non-coding RNA involved in cancer, neurobiology, and development. Front. Genet., 2012, 3, 270.
[http://dx.doi.org/10.3389/fgene.2012.00270] [PMID: 23226159]
[3]
Wang, T.; Zhu, H.; Xiao, M.; Zhou, S. Serum exosomal long noncoding RNA CRNDE as a prognostic biomarker for hepatocellular carcinoma. J. Clin. Lab. Anal., 2021, 35(11), e23959.
[http://dx.doi.org/10.1002/jcla.23959] [PMID: 34612554]
[4]
Chen, L.; Sun, L.; Dai, X.; Li, T.; Yan, X.; Zhang, Y.; Xiao, H.; Shen, X.; Huang, G.; Xiang, W.; Zhang, Y.; Tan, D.; Yang, S.; Nie, Y.; Huang, X.; Lian, J.; He, F. LncRNA CRNDE Promotes ATG4B-mediated autophagy and alleviates the sensitivity of sorafenib in hepatocellular carcinoma cells. Front. Cell Dev. Biol., 2021, 9, 687524.
[http://dx.doi.org/10.3389/fcell.2021.687524] [PMID: 34409031]
[5]
Xie, S.C.; Zhang, J.Q.; Jiang, X.L.; Hua, Y.Y.; Xie, S.W.; Qin, Y.A.; Yang, Y.J. LncRNA CRNDE facilitates epigenetic suppression of CELF2 and LATS2 to promote proliferation, migration and chemoresistance in hepatocellular carcinoma. Cell Death Dis., 2020, 11(8), 676.
[http://dx.doi.org/10.1038/s41419-020-02853-8] [PMID: 32826865]
[6]
Lin, C.; Xiang, Y.; Sheng, J.; Liu, S.; Cui, M.; Zhang, X. Long non-coding RNA CRNDE promotes malignant progression of hepatocellular carcinoma through the miR-33a-5p/CDK6 axis. J. Physiol. Biochem., 2020, 76(3), 469-481.
[http://dx.doi.org/10.1007/s13105-020-00754-0] [PMID: 32621257]
[7]
Li, Z.; Wu, G.; Li, J.; Wang, Y.; Ju, X.; Jiang, W. LncRNA CRNDE promotes the proliferation and metastasis by acting as sponge miR-539-5p to regulate POU2F1 expression in HCC. BMC Cancer, 2020, 20(1), 282.
[http://dx.doi.org/10.1186/s12885-020-06771-y] [PMID: 32252678]
[8]
Tang, D.; Zhao, L.; Peng, C.; Ran, K.; Mu, R.; Ao, Y. LncRNA CRNDE promotes hepatocellular carcinoma progression by upregulating SIX1 through modulating miR‐337‐ 3p. J. Cell. Biochem., 2019, 120(9), 16128-16142.
[http://dx.doi.org/10.1002/jcb.28894] [PMID: 31099050]
[9]
Ji, D.; Jiang, C.; Zhang, L.; Liang, N.; Jiang, T.; Yang, B.; Liang, H. Retracted: LncRNA CRNDE promotes hepatocellular carcinoma cell proliferation, invasion, and migration through regulating miR‐203/BCAT1 axis. J. Cell. Physiol., 2019, 234(5), 6548-6560.
[http://dx.doi.org/10.1002/jcp.27396] [PMID: 30230527]
[10]
Han, S.; Han, B.; Li, Z.; Sun, D. Downregulation of long noncoding RNA CRNDE suppresses drug resistance of liver cancer cells by increasing microRNA-33a expression and decreasing HMGA2 expression Cell Cycle, , 2019, 18(19), 2524-2537.
[http://dx.doi.org/10.1080/15384101.2019.1652035] [PMID: 31416393]
[11]
Zhu, L.; Yang, N.; Du, G.; Li, C.; Liu, G.; Liu, S.; Xu, Y.; Di, Y.; Pan, W.; Li, X. LncRNA CRNDE promotes the epithelial-mesenchymal transition of hepatocellular carcinoma cells via enhancing the Wnt/-catenin signaling pathway. J. Cell. Biochem., 2018.
[PMID: 30430650]
[12]
Wang, H.; Ke, J.; Guo, Q.; Barnabo Nampoukime, K.P.; Yang, P.; Ma, K. Long non-coding RNA CRNDE promotes the proliferation, migration and invasion of hepatocellular carcinoma cells through miR-217/MAPK1 axis. J. Cell. Mol. Med., 2018, 22(12), 5862-5876.
[http://dx.doi.org/10.1111/jcmm.13856] [PMID: 30246921]
[13]
Tang, Q.; Zheng, X.; Zhang, J. Long non-coding RNA CRNDE promotes heptaocellular carcinoma cell proliferation by regulating PI3K/Akt/β-catenin signaling. Biomed. Pharmacother., 2018, 103, 1187-1193.
[http://dx.doi.org/10.1016/j.biopha.2018.04.128] [PMID: 29864897]
[14]
Chen, Z.; Yu, C.; Zhan, L.; Pan, Y.; Chen, L.; Sun, C. LncRNA CRNDE promotes hepatic carcinoma cell proliferation, migration and invasion by suppressing miR-384. Am. J. Cancer Res., 2016, 6(10), 2299-2309.
[PMID: 27822419]
[15]
Zhang, F.; Wang, H.; Yu, J.; Yao, X.; Yang, S.; Li, W.; Xu, L.; Zhao, L. LncRNA CRNDE attenuates chemoresistance in gastric cancer via SRSF6-regulated alternative splicing of PICALM. Mol. Cancer, 2021, 20(1), 6.
[http://dx.doi.org/10.1186/s12943-020-01299-y] [PMID: 33397371]
[16]
Xin, L.; Zhou, L.Q.; Liu, C.; Zeng, F.; Yuan, Y.W.; Zhou, Q.; Li, S.H.; Wu, Y.; Wang, J.L.; Wu, D.Z.; Lu, H. Transfer of LncRNA CRNDE in TAM‐derived exosomes is linked with cisplatin resistance in gastric cancer. EMBO Rep., 2021, 22(12), e52124.
[http://dx.doi.org/10.15252/embr.202052124] [PMID: 34647680]
[17]
Hu, C.E.; Du, P.Z.; Zhang, H.D.; Huang, G.J. Long noncoding RNA CRNDE promotes proliferation of gastric cancer cells by targeting miR-145. Cell. Physiol. Biochem., 2017, 42(1), 13-21.
[http://dx.doi.org/10.1159/000477107] [PMID: 28490034]
[18]
Du, D.X.; Lian, D.B.; Amin, B.H.; Yan, W. Long non-coding RNA CRNDE is a novel tumor promoter by modulating PI3K/AKT signal pathways in human gastric cancer. Eur. Rev. Med. Pharmacol. Sci., 2017, 21(23), 5392-5398.
[PMID: 29243780]
[19]
Fu, D.; Zang, L.; Li, Z.; Fan, C.; Jiang, H.; Men, T. Long non-coding RNA CRNDE regulates the growth and migration of prostate cancer cells by targeting microRNA-146a-5p. Bioengineered, 2021, 12(1), 2469-2479.
[http://dx.doi.org/10.1080/21655979.2021.1935402] [PMID: 34232111]
[20]
Chen, J.H.; Tong, W.; Pu, X.F.; Wang, J.Z. Long noncoding RNA CRNDE promotes proliferation, migration and invasion in prostate cancer through miR-101/Rap1A. Neoplasma,, 2020, 67(3), 584-594.
[http://dx.doi.org/10.4149/neo_2020_190621N534] [PMID: 32182086]
[21]
Ai, Y.; Wu, S.; Gao, H.; Wei, H.; Tang, Z.; Li, X.; Zou, C. Repression of CRNDE enhances the anti‐tumour activity of CD8 + T cells against oral squamous cell carcinoma through regulating miR‐545‐5p and TIM‐3. J. Cell. Mol. Med., 2021, 25(23), 10857-10868.
[http://dx.doi.org/10.1111/jcmm.16909] [PMID: 34729919]
[22]
Ren, Y.; He, W.; Chen, W.; Ma, C.; Li, Y.; Zhao, Z.; Gao, T.; Ni, Q.; Chai, J.; Sun, M. Retracted: CRNDE promotes cell tongue squamous cell carcinoma cell growth and invasion through suppressing miR‐384. J. Cell. Biochem., 2019, 120(1), 155-163.
[http://dx.doi.org/10.1002/jcb.27206] [PMID: 30242873]
[23]
Dai, J.; Mu, J.W.; Mu, H. Long non coding RNA CRNDE regulates cell proliferation, migration, invasion, epithelial mesenchymal transition and apoptosis in oral squamous cell carcinoma. Oncol. Lett., 2019, 17(3), 3330-3340.
[http://dx.doi.org/10.3892/ol.2019.9978] [PMID: 30867767]
[24]
Huan, J.; Xing, L.; Lin, Q.; Xui, H.; Qin, X. Long noncoding RNA CRNDE activates Wnt/β-catenin signaling pathway through acting as a molecular sponge of microRNA-136 in human breast cancer. Am. J. Transl. Res., 2017, 9(4), 1977-1989.
[PMID: 28469804]
[25]
Sun, H.; He, L.; Ma, L.; Lu, T.; Wei, J.; Xie, K.; Wang, X. LncRNA CRNDE promotes cell proliferation, invasion and migration by competitively binding miR-384 in papillary thyroid cancer. Oncotarget, 2017, 8(66), 110552-110565.
[http://dx.doi.org/10.18632/oncotarget.22819] [PMID: 29299168]
[26]
David, A.; Zocchi, S.; Talbot, A.; Choisy, C.; Ohnona, A.; Lion, J.; Cuccuini, W.; Soulier, J.; Arnulf, B.; Bories, J.C.; Goodhardt, M.; Garrick, D. The long non-coding RNA CRNDE regulates growth of multiple myeloma cells via an effect on IL6 signalling. Leukemia, 2021, 35(6), 1710-1721.
[http://dx.doi.org/10.1038/s41375-020-01034-y] [PMID: 32879426]
[27]
David, A.; Zocchi, S.; Talbot, A.; Choisy, C.; Ohnona, A.; Lion, J.; Cuccuini, W.; Soulier, J.; Arnulf, B.; Bories, J.C.; Goodhardt, M.; Garrick, D. Correction to: The long non-coding RNA CRNDE regulates growth of multiple myeloma cells via an effect on IL6 signaling. Leukemia, 2021, 35(7), 2138.
[http://dx.doi.org/10.1038/s41375-021-01305-2] [PMID: 34099877]
[28]
Meng, Y.B.; He, X.; Huang, Y.F.; Wu, Q.N.; Zhou, Y.C.; Hao, D.J. Long noncoding RNA CRNDE promotes multiple myeloma cell growth by suppressing miR-451 Oncol. Res.., 2017, 25(7), 1207-1214.
[http://dx.doi.org/10.3727/096504017X14886679715637] [PMID: 28276319]
[29]
Ni, J.; Hong, J.; Li, Q.; Zeng, Q.; Xia, R. Long non-coding RNA CRNDE suppressing cell proliferation is regulated by DNA methylation in chronic lymphocytic leukemia. Leuk. Res., 2021, 105, 106564.
[http://dx.doi.org/10.1016/j.leukres.2021.106564] [PMID: 33857783]
[30]
Liu, C.; Zhong, L.; Shen, C.; Chu, X.; Luo, X.; Yu, L.; Ye, J.; Xiong, L.; Dan, W.; Li, J.; Liu, B. CRNDE enhances the expression of MCM5 and proliferation in acute myeloid leukemia KG-1a cells by sponging miR-136-5p. Sci. Rep., 2021, 11(1), 16755.
[http://dx.doi.org/10.1038/s41598-021-96156-3] [PMID: 34408205]
[31]
Hola, M.A.M.; Ali, M.A.M.; ElNahass, Y.; Salem, T.A.E.; Mohamed, M.R. Expression and prognostic relevance of long noncoding RNAs CRNDE and AOX2P in adult acute myeloid leukemia. Int. J. Lab. Hematol., 2021, 43(4), 732-742.
[http://dx.doi.org/10.1111/ijlh.13586] [PMID: 34129278]
[32]
Wang, W.; Wu, F.; Ma, P.; Gan, S.; Li, X.; Chen, L.; Sun, L.; Sun, H.; Jiang, Z.; Guo, F. LncRNA CRNDE promotes the progression of b-cell precursor acute lymphoblastic leukemia by targeting the miR-345-5p/CREB axis. Mol. Cells, 2020, 43(8), 718-727.
[PMID: 32868489]
[33]
Ma, X.; Zhang, W.; Zhao, M.; Li, S.; Jin, W.; Wang, K. Oncogenic role of lncRNA CRNDE in acute promyelocytic leukemia and NPM1-mutant acute myeloid leukemia. Cell Death Discov., 2020, 6(1), 121.
[http://dx.doi.org/10.1038/s41420-020-00359-y] [PMID: 33298855]
[34]
Kang, Y.; Zhang, S.; Cao, W.; Wan, D.; Sun, L. Knockdown of LncRNA CRNDE suppresses proliferation and P-glycoprotein-mediated multidrug resistance in acute myelocytic leukemia through the Wnt/-catenin pathway. Biosci. Rep., 2020, 40(6), BSR20193450.
[http://dx.doi.org/10.1042/BSR20193450] [PMID: 32426817]
[35]
Xu, L.; Zhang, Y.; Zhao, Z.; Chen, Z.; Wang, Z.; Xu, S.; Zhang, X.; Liu, T.; Yu, S. The long non-coding RNA CRNDE competed endogenously with miR-205 to promote proliferation and metastasis of melanoma cells by targeting CCL18 Cell Cycle,, 2018, 17(18), 2296-2308.
[http://dx.doi.org/10.1080/15384101.2018.1526602] [PMID: 30257602]
[36]
Yang, W.; Wang, Y.; Tao, C.; Li, Y.; Cao, S.; Yang, X. CRNDE silencing promotes apoptosis and enhances cisplatin sensitivity of colorectal carcinoma cells by inhibiting the Akt/mTORC1 mediated Warburg effect. Oncol. Lett., 2022, 23(2), 70.
[http://dx.doi.org/10.3892/ol.2022.13190] [PMID: 35069879]
[37]
Sun, J.; Jia, H.; Bao, X.; Wu, Y.; Zhu, T.; Li, R.; Zhao, H. Tumor exosome promotes Th17 cell differentiation by transmitting the lncRNA CRNDE-h in colorectal cancer. Cell Death Dis., 2021, 12(1), 123.
[http://dx.doi.org/10.1038/s41419-020-03376-y] [PMID: 33495437]
[38]
Liu, C.; Hou, J.; Shan, F.; Wang, L.; Lu, H.; Ren, T. Long non-coding RNA CRNDE promotes colorectal carcinoma cell progression and paclitaxel resistance by regulating miR-126-5p/ATAD2 Axis. OncoTargets Ther., 2020, 13, 4931-4942.
[http://dx.doi.org/10.2147/OTT.S237580] [PMID: 32581554]
[39]
Yu, B.; Ye, X.; Du, Q.; Zhu, B.; Zhai, Q.; Li, X.X. The long non-coding RNA CRNDE promotes colorectal carcinoma progression by competitively binding miR-217 with TCF7L2 and enhancing the Wnt/-catenin signaling pathway. Cell. Physiol. Biochem., 2017, 41(6), 2489-2502.
[http://dx.doi.org/10.1159/000475941] [PMID: 28472810]
[40]
Jiang, H.; Wang, Y.; Ai, M.; Wang, H.; Duan, Z.; Wang, H.; Zhao, L.; Yu, J.; Ding, Y.; Wang, S. Long noncoding RNA CRNDE stabilized by hnRNPUL2 accelerates cell proliferation and migration in colorectal carcinoma via activating Ras/MAPK signaling pathways. Cell Death Dis., 2017, 8(6), e2862.
[http://dx.doi.org/10.1038/cddis.2017.258] [PMID: 28594403]
[41]
Han, P.; Li, J.; Zhang, B.; Lv, J.; Li, Y.; Gu, X.; Yu, Z.; Jia, Y.; Bai, X.; Li, L.; Liu, Y.; Cui, B. The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/β-catenin signaling. Mol. Cancer, 2017, 16(1), 9.
[http://dx.doi.org/10.1186/s12943-017-0583-1] [PMID: 28086904]
[42]
Gao, H.; Song, X.; Kang, T.; Yan, B.; Feng, L.; Gao, L.; Ai, L.; Liu, X.; Yu, J.; Li, H. Long noncoding RNA CRNDE functions as a competing endogenous RNA to promote metastasis and oxaliplatin resistance by sponging miR-136 in colorectal cancer. OncoTargets Ther., 2017, 10, 205-216.
[http://dx.doi.org/10.2147/OTT.S116178] [PMID: 28115855]
[43]
Ding, J.; Li, J.; Wang, H.; Tian, Y.; Xie, M.; He, X.; Ji, H.; Ma, Z.; Hui, B.; Wang, K.; Ji, G. Long noncoding RNA CRNDE promotes colorectal cancer cell proliferation via epigenetically silencing DUSP5/CDKN1A expression. Cell Death Dis., 2017, 8(8), e2997.
[http://dx.doi.org/10.1038/cddis.2017.328] [PMID: 28796262]
[44]
Sorokin, M.; Raevskiy, M.; Zottel, A.; Šamec, N.; Skoblar Vidmar, M. Matjašič A.; Zupan, A.; Mlakar, J.; Suntsova, M.; Kuzmin, D.V.; Buzdin, A.; Jovč evska, I. Large-scale transcriptomics-driven approach revealed overexpression of CRNDE as a poor survival prognosis biomarker in glioblastoma. Cancers (Basel), 2021, 13(14), 3419.
[http://dx.doi.org/10.3390/cancers13143419] [PMID: 34298634]
[45]
Luo, X.; Tu, T.; Zhong, Y.; Xu, S.; Chen, X.; Chen, L.; Yang, F. ceRNA Network analysis shows that lncRNA CRNDE promotes progression of glioblastoma through sponge mir-9-5p. Front. Genet., 2021, 12, 617350.
[http://dx.doi.org/10.3389/fgene.2021.617350] [PMID: 33767729]
[46]
Hu, Y.; Luo, H.; Zhu, X.; Guo, H. CRNDE/ETS1/GPR17 facilitates the proliferation, migration, and invasion of glioma. Comput. Math. Methods Med., 2021, 2021, 1-11.
[http://dx.doi.org/10.1155/2021/7566365] [PMID: 34853603]
[47]
Li, D.X.; Fei, X.R.; Dong, Y.F.; Cheng, C.D.; Yang, Y.; Deng, X.F.; Huang, H.L.; Niu, W.X.; Zhou, C.X.; Xia, C.Y.; Niu, C.S. The long non-coding RNA CRNDE acts as a ceRNA and promotes glioma malignancy by preventing miR-136-5p-mediated downregulation of Bcl-2 and Wnt2. Oncotarget, 2017, 8(50), 88163-88178.
[http://dx.doi.org/10.18632/oncotarget.21513] [PMID: 29152149]
[48]
Kiang, K.M.Y.; Zhang, X.Q.; Zhang, G.P.; Li, N.; Cheng, S.Y.; Poon, M.W.; Pu, J.K.S.; Lui, W.M.; Leung, G.K.K. CRNDE expression positively correlates with EGFR activation and modulates glioma cell growth. Target. Oncol., 2017, 12(3), 353-363.
[http://dx.doi.org/10.1007/s11523-017-0488-3] [PMID: 28493025]
[49]
Zheng, J.; Liu, X.; Wang, P.; Xue, Y.; Ma, J.; Qu, C.; Liu, Y. RETRACTED: CRNDE Promotes Malignant Progression of Glioma by Attenuating miR-384/PIWIL4/STAT3 Axis. Mol. Ther., 2016, 24(7), 1199-1215.
[http://dx.doi.org/10.1038/mt.2016.71] [PMID: 27058823]
[50]
Zheng, J.; Li, X.; Wang, P.; Liu, X.; Xue, Y.; Hu, Y.; Li, Z.; Li, Z.; Wang, Z.; Liu, Y. CRNDE affects the malignant biological characteristics of human glioma stem cells by negatively regulating miR-186. Oncotarget, 2015, 6(28), 25339-25355.
[http://dx.doi.org/10.18632/oncotarget.4509] [PMID: 26231038]
[51]
Wang, Y.; Wang, Y.; Li, J.; Zhang, Y.; Yin, H.; Han, B. CRNDE, a long-noncoding RNA, promotes glioma cell growth and invasion through mTOR signaling. Cancer Lett., 2015, 367(2), 122-128.
[http://dx.doi.org/10.1016/j.canlet.2015.03.027] [PMID: 25813405]
[52]
Yu, Y.; Wang, L.; Li, Z.; Zheng, Y.; Shi, Z.; Wang, G. Long noncoding RNA CRNDE functions as a diagnostic and prognostic biomarker in osteosarcoma, as well as promotes its progression via inhibition of miR-335-3p. J. Biochem. Mol. Toxicol., 2021, 35(5), e22734.
[http://dx.doi.org/10.1002/jbt.22734] [PMID: 33522065]
[53]
Ding, Q.; Mo, F.; Cai, X.; Zhang, W.; Wang, J.; Yang, S.; Liu, X. LncRNA CRNDE is activated by SP1 and promotes osteosarcoma proliferation, invasion, and epithelial‐mesenchymal transition via Wnt/β‐catenin signaling pathway. J. Cell. Biochem., 2020, 121(5-6), 3358-3371.
[http://dx.doi.org/10.1002/jcb.29607] [PMID: 31898343]
[54]
Li, Z.; Tang, Y.; Xing, W.; Dong, W.; Wang, Z. LncRNA, CRNDE promotes osteosarcoma cell proliferation, invasion and migration by regulating Notch1 signaling and epithelial-mesenchymal transition. Exp. Mol. Pathol., 2018, 104(1), 19-25.
[http://dx.doi.org/10.1016/j.yexmp.2017.12.002] [PMID: 29246789]
[55]
Ren, L.; Yang, S.; Cao, Q.; Tian, J. CRNDE contributes cervical cancer progression by regulating miR-4262/ZEB1 axis. OncoTargets Ther., 2021, 14, 355-366.
[http://dx.doi.org/10.2147/OTT.S263505] [PMID: 33469312]
[56]
Bai, X.; Wang, W.; Zhao, P.; Wen, J.; Guo, X.; Shen, T.; Shen, J.; Yang, X. LncRNA CRNDE acts as an oncogene in cervical cancer through sponging miR-183 to regulate CCNB1 expression. Carcinogenesis, 2020, 41(1), 111-121.
[http://dx.doi.org/10.1093/carcin/bgz166] [PMID: 31605132]
[57]
Zhang, J.J.; Fan, L.P. Long non-coding RNA CRNDE enhances cervical cancer progression by suppressing PUMA expression. Biomed. Pharmacother., 2019, 117, 108726.
[http://dx.doi.org/10.1016/j.biopha.2019.108726] [PMID: 31202167]
[58]
Yang, H.Y.; Huang, C.P.; Cao, M.M.; Wang, Y.F.; Liu, Y. Long non-coding RNA CRNDE may be associated with poor prognosis by promoting proliferation and inhibiting apoptosis of cervical cancer cells through targeting PI3K/AKT. Neoplasma,, 2018, 65(6), 872-880.
[http://dx.doi.org/10.4149/neo_2018_171225N841] [PMID: 30334449]
[59]
Meng, Y.; Li, Q.; Li, L.; Ma, R. The long non-coding RNA CRNDE promotes cervical cancer cell growth and metastasis. Biol. Chem., 2017, 399(1), 93-100.
[http://dx.doi.org/10.1515/hsz-2017-0199] [PMID: 29194035]
[60]
Xia, X.L.; Xue, D.; Xiang, T.H.; Xu, H.Y.; Song, D.K.; Cheng, P.G.; Wang, J.Q. Overexpression of long non coding RNA CRNDE facilitates epithelial mesenchymal transition and correlates with poor prognosis in intrahepatic cholangiocarcinoma. Oncol. Lett., 2018, 15(4), 4105-4112.
[http://dx.doi.org/10.3892/ol.2018.7815] [PMID: 29556285]
[61]
Takahashi, S.; Noro, R.; Seike, M.; Zeng, C.; Matsumoto, M.; Yoshikawa, A.; Nakamichi, S.; Sugano, T.; Hirao, M.; Matsuda, K.; Hamada, M.; Gemma, A. Long non-coding RNA CRNDE is involved in resistance to EGFR tyrosine kinase inhibitor in EGFR-mutant lung cancer via eIF4A3/MUC1/EGFR signaling. Int. J. Mol. Sci., 2021, 22(8), 4005.
[http://dx.doi.org/10.3390/ijms22084005] [PMID: 33924522]
[62]
Jing, H.; Xia, H.; Qian, M.; Lv, X. Long noncoding RNA CRNDE promotes non-small cell lung cancer progression via sponging microRNA-338-3p. Biomed. Pharmacother., 2019, 110, 825-833.
[http://dx.doi.org/10.1016/j.biopha.2018.12.024] [PMID: 30554121]
[63]
Fan, Y.F.; Yu, Z.P.; Cui, X.Y. lncRNA colorectal neoplasia differentially expressed (CRNDE) promotes proliferation and inhibits apoptosis in non-small cell lung cancer cells by regulating the miR-641/CDK6 axis. Med. Sci. Monit., 2019, 25, 2745-2755.
[http://dx.doi.org/10.12659/MSM.913420] [PMID: 30982057]
[64]
Zhang, M.; Gao, C.; Yang, Y.; Li, G.; Dong, J.; Ai, Y.; Chen, N.; Li, W. Long noncoding RNA CRNDE/PRC2 participated in the radiotherapy resistance of human lung adenocarcinoma through targeting p21 expression. Oncol. Res., 2018, 26(8), 1245-1255.
[http://dx.doi.org/10.3727/096504017X14944585873668] [PMID: 28550688]
[65]
Liu, X.X.; Xiong, H.P.; Huang, J.S.; Qi, K.; Xu, J.J. Highly expressed long non-coding RNA CRNDE promotes cell proliferation through PI3K/AKT signalling in non-small cell lung carcinoma. Clin. Exp. Pharmacol. Physiol., 2017, 44(8), 895-902.
[http://dx.doi.org/10.1111/1440-1681.12780] [PMID: 28477368]
[66]
Chen, L.J.; Yuan, M.X.; Ji, C.Y.; Zhang, Y.B.; Peng, Y.M.; Zhang, T.; Gao, H.Q.; Sheng, X.Y.; Liu, Z.Y.; Xie, W.X.; Yin, Q. Long Non-Coding RNA CRNDE regulates angiogenesis in hepatoblastoma by targeting the MiR-203/VEGFA axis. Pathobiology, 2020, 87(3), 161-170.
[http://dx.doi.org/10.1159/000505131] [PMID: 32182608]
[67]
Dong, R.; Liu, X.Q.; Zhang, B.B.; Liu, B.H.; Zheng, S.; Dong, K.R. Long non-coding RNA-CRNDE: A novel regulator of tumor growth and angiogenesis in hepatoblastoma. Oncotarget, 2017, 8(26), 42087-42097.
[http://dx.doi.org/10.18632/oncotarget.14992] [PMID: 28178668]
[68]
Li, K.; Cui, M.; Zhang, K.; Wang, G.; Zhai, S. LncRNA CRNDE affects the proliferation and apoptosis of vascular smooth muscle cells in abdominal aortic aneurysms by regulating the expression of Smad3 by Bcl-3 Cell Cycle,, 2020, 19(9), 1036-1047.
[http://dx.doi.org/10.1080/15384101.2020.1743915] [PMID: :32240036]
[69]
Sun, Y.; Zhang, L.; Wu, Q.; Xu, C.; Wang, P. Long noncoding RNA CRNDE functions as an oncogene to facilitate aggressive behaviors of nasopharyngeal carcinoma cells by modulating miR-3163/TWIST1 axis. Mol. Biotechnol., 2022, 64(4), 463-471.
[PMID: 34796452]
[70]
Ge, S.; Jiang, C.; Li, M.; Cheng, Z.; Feng, X. Long non-coding RNA CRNDE exacerbates NPC advancement mediated by the miR-545-5p/CCND2 axis. Cancer Cell Int., 2021, 21(1), 650.
[http://dx.doi.org/10.1186/s12935-021-02348-2] [PMID: 34863152]
[71]
Cheng, J.; Chen, J.; Zhang, X.; Mei, H.; Wang, F.; Cai, Z. Overexpression of CRNDE promotes the progression of bladder cancer. Biomed. Pharmacother., 2018, 99, 638-644.
[http://dx.doi.org/10.1016/j.biopha.2017.12.055] [PMID: 29710461]
[72]
Cui, W.W.; Sun, Y.L.; Chen, C.; Feng, R.R.; Xu, W.; Meng, J.J.; Zhang, K. LncRNA CRNDE promotes the development of Wilms’ tumor by regulating microRNA-424. Eur. Rev. Med. Pharmacol. Sci., 2020, 24(3), 1088-1097.
[PMID: 32096178]
[73]
Sun, X.; Fan, W.; An, Z.; Sun, Y. Inhibition of long noncoding RNA CRNDE increases chemosensitivity of medulloblastoma cells by targeting miR-29c-3p Oncol. Res., 2020, 28(1), 95-102.
[http://dx.doi.org/10.3727/096504019X15742472027401] [PMID: 31753063]
[74]
Song, H.; Han, L.M.; Gao, Q.; Sun, Y. Long non-coding RNA CRNDE promotes tumor growth in medulloblastoma. Eur. Rev. Med. Pharmacol. Sci., 2016, 20(12), 2588-2597.
[PMID: 27383309]
[75]
Zhu, H.Y.; Gao, Y.J.; Wang, Y.; Liang, C.; Zhang, Z.X.; Chen, Y. LncRNA CRNDE promotes the progression and angiogenesis of pancreatic cancer via miR-451a/CDKN2D axis. Transl. Oncol., 2021, 14(7), 101088.
[http://dx.doi.org/10.1016/j.tranon.2021.101088] [PMID: 33882369]
[76]
Wang, G.; Pan, J.; Zhang, L.; Wei, Y.; Wang, C. Long non-coding RNA CRNDE sponges miR-384 to promote proliferation and metastasis of pancreatic cancer cells through upregulating IRS1. Cell Prolif., 2017, 50(6), e12389.
[http://dx.doi.org/10.1111/cpr.12389] [PMID: 28940804]
[77]
Shen, S.; Liu, H.; Wang, Y.; Wang, J.; Ni, X.; Ai, Z.; Pan, H.; Liu, H.; Shao, Y. Long non-coding RNA CRNDE promotes gallbladder carcinoma carcinogenesis and as a scaffold of DMBT1 and C-IAP1 complexes to activating PI3K-AKT pathway. Oncotarget, 2016, 7(45), 72833-72844.
[http://dx.doi.org/10.18632/oncotarget.12023] [PMID: 27637083]
[78]
Wang, Q.; Wang, L.X.; Zhang, C.Y.; Bai, N.; Feng, C.; Zhang, Z.M.; Wang, L.; Gao, Z.Z. LncRNA CRNDE promotes cell proliferation, migration and invasion of ovarian cancer via miR-423-5p/FSCN1 axis. Mol. Cell. Biochem., 2022, 477(5), 1477-1488.
[http://dx.doi.org/10.1007/s11010-022-04382-8] [PMID: 35166986]
[79]
Szafron, L.M.; Balcerak, A.; Grzybowska, E.A.; Pienkowska-Grela, B.; Podgorska, A.; Zub, R.; Olbryt, M.; Pamula-Pilat, J.; Lisowska, K.M.; Grzybowska, E.; Rubel, T.; Dansonka-Mieszkowska, A.; Konopka, B.; Kulesza, M.; Lukasik, M.; Kupryjanczyk, J. The putative oncogene, CRNDE, is a negative prognostic factor in ovarian cancer patients. Oncotarget, 2015, 6(41), 43897-43910.
[http://dx.doi.org/10.18632/oncotarget.6016] [PMID: 26556866]
[80]
Zhang, Y.; Lan, X.; Wang, Y.; Liu, C.; Cui, T. CRNDE mediates the viability and epithelial–mesenchymal transition of renal cell carcinoma via miR-136-5p. J. Recept. Signal Transduct. Res.,, 2021, 41(3), 234-244.
[http://dx.doi.org/10.1080/10799893.2020.1805629] [PMID: 32808846]
[81]
Ding, C.; Han, F.; Xiang, H.; Xia, X.; Wang, Y.; Dou, M.; Zheng, J.; Li, Y.; Xue, W.; Ding, X.; Tian, P. LncRNA CRNDE is a biomarker for clinical progression and poor prognosis in clear cell renal cell carcinoma. J. Cell. Biochem., 2018, 119(12), 10406-10414.
[http://dx.doi.org/10.1002/jcb.27389] [PMID: 30129055]
[82]
Shao, K.; Shi, T.; Yang, Y.; Wang, X.; Xu, D.; Zhou, P. Highly expressed lncRNA CRNDE promotes cell proliferation through Wnt/β-catenin signaling in renal cell carcinoma. Tumour Biol., 2016, 37(12), 15997-16004.
[http://dx.doi.org/10.1007/s13277-016-5440-0] [PMID: 27714674]
[83]
Zhao, Z.; Liu, M.; Long, W.; Yuan, J.; Li, H.; Zhang, C.; Tang, G.; Jiang, W.; Yuan, X.; Wu, M.; Liu, Q. Knockdown lncRNA CRNDE enhances temozolomide chemosensitivity by regulating autophagy in glioblastoma. Cancer Cell Int., 2021, 21(1), 456.
[http://dx.doi.org/10.1186/s12935-021-02153-x] [PMID: 34454479]
[84]
Huang, X.L.; Zhang, G.M. Serum exosomal long noncoding RNA CRNDE level for hepatocellular carcinoma diagnosis. J. Clin. Lab. Anal., 2022, 36(1), e24144.
[http://dx.doi.org/10.1002/jcla.24144] [PMID: 34825722]
[85]
He, T.Y.; Li, S.H.; Huang, J.; Gong, M.; Li, G. Prognostic value of long non-coding RNA CRNDE in gastrointestinal cancers: A meta-analysis. Cancer Manag. Res., 2019, 11, 5629-5642.
[http://dx.doi.org/10.2147/CMAR.S201646] [PMID: 31296996]

Rights & Permissions Print Cite
Article Metrics
34
2
World Chagas Disease
© 2024 Bentham Science Publishers | Privacy Policy