Login Register Cart 0
Generic placeholder image

Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe Translate in Chinese
Review Article

Curcumin Nanofibers: A Novel Approach to Enhance the Anticancer Potential and Bioavailability of Curcuminoids

Author(s): Mahshid Ataei, Basil D. Roufogalis, Muhammed Majeed, Muhammad A. Shah and Amirhossein Sahebkar*

Volume 30, Issue 3, 2023

Published on: 20 May, 2022

Page: [286 - 303] Pages: 18

DOI: 10.2174/0929867329666220322110348

Price: $65

Abstract

Development of novel treatment methods for cancer is needed given the limitations of current treatment methods, including side effects and chemotherapeutic resistance, which may provide new hope to cancer patients. Cancer is the second leading cause of global mortality. Curcumin, the active ingredient of turmeric, has been used since ancient times for various therapeutic purposes. Several studies have identified its activity against cancer. Despite the established anticancer activity of curcumin, its low aqueous solubility and bioavailability are barriers to its effectiveness. In an attempt to solve this problem, many studies have formulated curcumin nanofiber preparations using a variety of methods. Electrospinning is a simple and affordable method for the production of nanofibers. Studies have shown increased curcumin bioavailability in nanofibers resulting from their high surface/volume ratio and porosity. We have undertaken a detailed review of studies on the anticancer effects of curcumin nanofibers. Curcumin acts by inhibiting various biological cancer pathways, including NF-κB, mTOR, complex I, cytokines, expression of p-p65, Ki67, and angiogenesis-associated genes. It also induces apoptosis through activation of caspase pathways and ROS production in cancer cells. Curcumin-loaded PLA50/PVP50/Cur15 nanofibers were investigated in breast cancer, one of the most studied cancers, and was shown to have significant effects on the widely used HeLa-cell line. Most of the studies undertaken have been performed in cell lines in vitro, while relatively few animal studies have been reported. More preclinical and clinical studies are needed to evaluate the anticancer activity of curcumin nanofibers. Amongst studies undertaken, a variety of curcumin nanofibers of various formulations have been shown to suppress a variety of cancer types. Overall, curcumin nanofibers have been found to be more efficient than free curcumin. Thus, curcumin nanofibers have been observed to improvise cancer treatment, offering great potential for effective cancer management. Further studies, both in vitro and in vivo, involving curcumin nanofibers have the potential to benefit cancer management.

Keywords: Curcumin, nanofiber, cancer, electrospinning, bioavailability of curcuminoids, chemotherapeutic resistance.

« Previous Next »
[1]
Abd Wahab, N.A.; Lajis, N.H.; Abas, F.; Othman, I.; Naidu, R. Mechanism of anti-cancer activity of curcumin on androgen-dependent and androgen-independent prostate cancer. Nutrients, 2020, 12(3), E679.
[http://dx.doi.org/10.3390/nu12030679] [PMID: 32131560]
[2]
Kalluru, H.; Kondaveeti, S.S.; Telapolu, S.; Kalachaveedu, M. Turmeric supplementation improves the quality of life and hematological parameters in breast cancer patients on paclitaxel chemotherapy: A case series. Complement. Ther. Clin. Pract., 2020, 41, 101247.
[http://dx.doi.org/10.1016/j.ctcp.2020.101247] [PMID: 33099272]
[3]
Wong, K.E.; Ngai, S.C.; Chan, K-G.; Lee, L-H.; Goh, B-H.; Chuah, L-H. Curcumin nanoformulations for colorectal cancer: A review. Front. Pharmacol., 2019, 10, 152.
[http://dx.doi.org/10.3389/fphar.2019.00152] [PMID: 30890933]
[4]
Menon, V.P.; Sudheer, A.R. Antioxidant and anti-inflammatory properties of curcumin. Adv. Exp. Med. Biol., 2007, 595, 105-125.
[http://dx.doi.org/10.1007/978-0-387-46401-5_3] [PMID: 17569207]
[5]
Pulido-Moran, M.; Moreno-Fernandez, J.; Ramirez-Tortosa, C.; Ramirez-Tortosa, M. Curcumin and health. Molecules, 2016, 21(3), 264.
[http://dx.doi.org/10.3390/molecules21030264] [PMID: 26927041]
[6]
Chainani-Wu, N. Safety and anti-inflammatory activity of curcumin: A component of tumeric (Curcuma longa). J. Altern. Complement. Med., 2003, 9(1), 161-168.
[http://dx.doi.org/10.1089/107555303321223035] [PMID: 12676044]
[7]
Farhood, B.; Mortezaee, K.; Goradel, N.H.; Khanlarkhani, N.; Salehi, E.; Nashtaei, M.S.; Najafi, M.; Sahebkar, A. Curcumin as an anti-inflammatory agent: Implications to radiotherapy and chemotherapy. J. Cell. Physiol., 2019, 234(5), 5728-5740.
[http://dx.doi.org/10.1002/jcp.27442]
[8]
Jiang, S.; Han, J.; Li, T.; Xin, Z.; Ma, Z.; Di, W.; Hu, W.; Gong, B.; Di, S.; Wang, D.; Yang, Y. Curcumin as a potential protective compound against cardiac diseases. Pharmacol. Res., 2017, 119, 373-383.
[http://dx.doi.org/10.1016/j.phrs.2017.03.001] [PMID: 28274852]
[9]
Srivastava, G.; Mehta, J.L. Currying the heart: Curcumin and cardioprotection. J. Cardiovasc. Pharmacol. Ther., 2009, 14(1), 22-27.
[http://dx.doi.org/10.1177/1074248408329608] [PMID: 19153099]
[10]
Samarghandian, S.; Azimi-Nezhad, M.; Farkhondeh, T.; Samini, F. Anti-oxidative effects of curcumin on immobilization-induced oxidative stress in rat brain, liver and kidney. Biomed. Pharmacother., 2017, 87, 223-229.
[http://dx.doi.org/10.1016/j.biopha.2016.12.105] [PMID: 28061405]
[11]
Chuengsamarn, S.; Rattanamongkolgul, S.; Luechapudiporn, R.; Phisalaphong, C.; Jirawatnotai, S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care, 2012, 35(11), 2121-2127.
[http://dx.doi.org/10.2337/dc12-0116] [PMID: 22773702]
[12]
Pivari, F.; Mingione, A.; Brasacchio, C.; Soldati, L. Curcumin and Type 2 Diabetes Mellitus: Prevention and treatment. Nutrients, 2019, 11(8), E1837.
[http://dx.doi.org/10.3390/nu11081837] [PMID: 31398884]
[13]
Parsamanesh, N.; Moossavi, M.; Bahrami, A.; Butler, A.E.; Sahebkar, A. Therapeutic potential of curcumin in diabetic complications. Pharmacolo. Res.,2018, 136, 181-193.
[http://dx.doi.org/10.1016/j.phrs.2018.09.012]
[14]
Panahi, Y.; Khalili, N.; Sahebi, E.; Namazi, S.; Reiner, Ž.; Majeed, M.; Sahbekar, A. Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial. Complement. Ther. Med., 2017, 33, 1-5.
[http://dx.doi.org/10.1016/j.ctim.2017.05.006]
[15]
Reddy, P.H.; Manczak, M.; Yin, X.; Grady, M.C.; Mitchell, A.; Tonk, S.; Kuruva, C.S.; Bhatti, J.S.; Kandimalla, R.; Vijayan, M.; Kumar, S.; Wang, R.; Pradeepkiran, J.A.; Ogunmokun, G.; Thamarai, K.; Quesada, K.; Boles, A.; Reddy, A.P. Protective effects of indian spice curcumin against Amyloid-β in Alzheimer’s Disease. J. Alzheimers Dis., 2018, 61(3), 843-866.
[http://dx.doi.org/10.3233/JAD-170512] [PMID: 29332042]
[16]
Small, G.W.; Siddarth, P.; Li, Z.; Miller, K.J.; Ercoli, L.; Emerson, N.D.; Martinez, J.; Wong, K.P.; Liu, J.; Merrill, D.A.; Chen, S.T.; Henning, S.M.; Satyamurthy, N.; Huang, S.C.; Heber, D.; Barrio, J.R. Memory and brain amyloid and Tau effects of a bioavailable form of curcumin in non-demented adults: A double-blind, placebo-controlled 18-month trial. Am. J. Geriatr. Psychiatry, 2018, 26(3), 266-277.
[http://dx.doi.org/10.1016/j.jagp.2017.10.010] [PMID: 29246725]
[17]
Asteriou, E.; Gkoutzourelas, A.; Mavropoulos, A.; Katsiari, C.; Sakkas, L.I.; Bogdanos, D.P. Curcumin for the management of periodontitis and early ACPA-positive rheumatoid arthritis: Killing two birds with one stone. Nutrients, 2018, 10(7), E908.
[http://dx.doi.org/10.3390/nu10070908] [PMID: 30012973]
[18]
Chandran, B.; Goel, A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother. Res., 2012, 26(11), 1719-1725.
[http://dx.doi.org/10.1002/ptr.4639] [PMID: 22407780]
[19]
Daily, J.W.; Yang, M.; Park, S. Efficacy of turmeric extracts and curcumin for alleviating the symptoms of joint arthritis: A systematic review and meta-analysis of randomized clinical trials. J. Med. Food, 2016, 19(8), 717-729.
[http://dx.doi.org/10.1089/jmf.2016.3705] [PMID: 27533649]
[20]
Adiwidjaja, J.; McLachlan, A.J.; Boddy, A.V. Curcumin as a clinically-promising anti-cancer agent: Pharmacokinetics and drug interactions. Expert Opin. Drug Metab. Toxicol., 2017, 13(9), 953-972.
[http://dx.doi.org/10.1080/17425255.2017.1360279] [PMID: 28776444]
[21]
Hassanalilou, T.; Ghavamzadeh, S.; Khalili, L. Curcumin and gastric cancer: A review on mechanisms of action. J. Gastrointest. Cancer, 2019, 50(2), 185-192.
[http://dx.doi.org/10.1007/s12029-018-00186-6] [PMID: 30725357]
[22]
Howells, L.M.; Iwuji, C.O.O.; Irving, G.R.B.; Barber, S.; Walter, H.; Sidat, Z.; Griffin-Teall, N.; Singh, R.; Foreman, N.; Patel, S.R.; Morgan, B.; Steward, W.P.; Gescher, A.; Thomas, A.L.; Brown, K. Curcumin combined with FOLFOX chemotherapy is safe and tolerable in patients with metastatic colorectal cancer in a Randomized Phase IIa Trial. J. Nutr., 2019, 149(7), 1133-1139.
[http://dx.doi.org/10.1093/jn/nxz029] [PMID: 31132111]
[23]
Shahcheraghi, S.H.; Zangui, M.; Lotfi, M.; Ghayour-Mobarhan, M.; Ghorbani, A.; Jaliani, H.Z.; Sadeghnia, H.R.; Sahebkar, A. Therapeutic potential of curcumin in the treatment of glioblastoma multiforme. Curr. Pharm. Des., 2019, 25(3), 333-342.
[http://dx.doi.org/10.2174/1381612825666190313123704] [PMID: 30864499]
[24]
Wan Mohd Tajuddin, W.N.B.; Lajis, N.H.; Abas, F.; Othman, I.; Naidu, R. Mechanistic understanding of curcumin’s therapeutic effects in lung cancer. Nutrients, 2019, 11(12), E2989.
[http://dx.doi.org/10.3390/nu11122989] [PMID: 31817718]
[25]
Wang, Y.; Yu, J.; Cui, R.; Lin, J.; Ding, X. Curcumin in treating breast cancer: A review. J. Lab. Autom., 2016, 21(6), 723-731.
[http://dx.doi.org/10.1177/2211068216655524] [PMID: 27325106]
[26]
Giordano, A.; Tommonaro, G. Curcumin and cancer. Nutrients, 2019, 11(10), 2376.
[http://dx.doi.org/10.3390/nu11102376] [PMID: 31590362]
[27]
Batra, H.; Pawar, S.; Bahl, D. Curcumin in combination with anti-cancer drugs: A nanomedicine review. Pharmacol. Res., 2019, 139, 91-105.
[http://dx.doi.org/10.1016/j.phrs.2018.11.005] [PMID: 30408575]
[28]
Hu, C.; Li, M.; Guo, T.; Wang, S.; Huang, W.; Yang, K.; Liao, Z.; Wang, J.; Zhang, F.; Wang, H. Anti-metastasis activity of curcumin against breast cancer via the inhibition of stem cell-like properties and EMT. Phytomedicine, 2019, 58, 152740.
[http://dx.doi.org/10.1016/j.phymed.2018.11.001] [PMID: 31005718]
[29]
Aytac, Z.; Uyar, T. Core-shell nanofibers of curcumin/cyclodextrin inclusion complex and polylactic acid: Enhanced water solubility and slow release of curcumin. Int. J. Pharm., 2017, 518(1-2), 177-184.
[http://dx.doi.org/10.1016/j.ijpharm.2016.12.061] [PMID: 28057465]
[30]
Celebioglu, A.; Uyar, T. Fast-dissolving antioxidant curcumin/cyclodextrin inclusion complex electrospun nanofibrous webs. Food Chem., 2020, 317, 126397.
[http://dx.doi.org/10.1016/j.foodchem.2020.126397] [PMID: 32078994]
[31]
Ibrahim, H.M.; Klingner, A. A review on electrospun polymeric nanofibers: Production parameters and potential applications. Polym. Test., 2020, 90, 106647.
[http://dx.doi.org/10.1016/j.polymertesting.2020.106647]
[32]
Kumar, P.S.; Jayaraman, S.; Singh, G. Polymer and composite nanofiber: Electrospinning parameters and rheology properties. In: Rheology and Processing of Polymer Nanocomposites; Springer, 2016; pp. 329-354.
[33]
Islam, M.S.; Ang, B.C.; Andriyana, A.; Afifi, A.M. A review on fabrication of nanofibers via electrospinning and their applications. SN Appl. Sci., 2019, 1(10), 1-16.
[http://dx.doi.org/10.1007/s42452-019-1288-4]
[34]
Akhgari, A.; Shakib, Z.; Sanati, S. A review on electrospun nanofibers for oral drug delivery. Nanomed. J., 2017, 4(4), 197-207.
[35]
Ranjbar-Mohammadi, M.; Bahrami, S.H. Electrospun curcumin loaded poly(ε-caprolactone)/gum tragacanth nanofibers for biomedical application. Int. J. Biol. Macromol., 2016, 84, 448-456.
[http://dx.doi.org/10.1016/j.ijbiomac.2015.12.024] [PMID: 26706845]
[36]
Afzali, M.; Mostafavi, A.; Shamspur, T. Electrospun composite nanofibers of poly vinyl pyrrolidone and Zinc Oxide nanoparticles modified Carbon paste electrode for electrochemical detection of curcumin. Mater. Sci. Eng. C, 2016, 68, 789-797.
[http://dx.doi.org/10.1016/j.msec.2016.07.038] [PMID: 27524081]
[37]
Boroumand, S.; Hosseini, S.; Pashandi, Z.; Faridi-Majidi, R.; Salehi, M. Curcumin-loaded nanofibers for targeting endometriosis in the peritoneum of a mouse model. J. Mater. Sci. Mater. Med., 2019, 31(1), 8.
[http://dx.doi.org/10.1007/s10856-019-6337-4] [PMID: 31838602]
[38]
Yakub, G.; Toncheva, A.; Kussovski, V.; Toshkova, R.; Georgieva, A.; Nikolova, E. Curcumin-PVP loaded electrospun membranes with conferred antibacterial and antitumoral activities. Fibers Polym., 2020, 21(1), 55-65.
[http://dx.doi.org/10.1007/s12221-020-9473-z]
[39]
Ma, Y.; Wang, X.; Zong, S.; Zhang, Z.; Xie, Z.; Huang, Y.; Yue, Y.; Liu, S.; Jing, X. Local, combination chemotherapy in prevention of cervical cancer recurrence after surgery by using nanofibers co-loaded with cisplatin and curcumin. RSC Advances, 2015, 5(129), 106325-106332.
[http://dx.doi.org/10.1039/C5RA17230F]
[40]
Thangaraju, E.; Srinivasan, N.T.; Kumar, R.; Sehgal, P.K.; Rajiv, S. Fabrication of electrospun Poly L-lactide and Curcumin loaded Poly L-lactide nanofibers for drug delivery. Fibers Polym., 2012, 13, 823-830.
[http://dx.doi.org/10.1007/s12221-012-0823-3]
[41]
Guo, G.; Fu, S.; Zhou, L.; Liang, H.; Fan, M.; Luo, F.; Qian, Z.; Wei, Y. Preparation of curcumin loaded poly(ε- caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) nanofibers and their in vitro antitumor activity against Glioma 9L cells. Nanoscale, 2011, 3(9), 3825-3832.
[http://dx.doi.org/10.1039/c1nr10484e] [PMID: 21847493]
[42]
Kumar, S.U.; Matai, I.; Dubey, P.; Bhushan, B.; Sachdev, A.; Gopinath, P. Differentially cross-linkable core–shell nanofibers for tunable delivery of anticancer drugs: synthesis, characterization and their anticancer efficacy. RSC Advances, 2014, 4(72), 38263-38272.
[http://dx.doi.org/10.1039/C4RA05001K]
[43]
Sridhar, R.; Ravanan, S.; Venugopal, J.R.; Sundarrajan, S.; Pliszka, D.; Sivasubramanian, S.; Gunasekaran, P.; Prabhakaran, M.; Madhaiyan, K.; Sahayaraj, A.; Lim, K.H.; Ramakrishna, S. Curcumin- and natural extract-loaded nanofibres for potential treatment of lung and breast cancer: In vitro efficacy evaluation. J. Biomater. Sci. Polym. Ed., 2014, 25(10), 985-998.
[http://dx.doi.org/10.1080/09205063.2014.917039] [PMID: 24865590]
[44]
Bulbul, Y.E.; Okur, M.; Demirtas-Korkmaz, F.; Dilsiz, N. Development of PCL/PEO electrospun fibrous membranes blended with silane-modified halloysite nanotube as a curcumin release system. Appl. Clay Sci., 2020, 186, 105430.
[45]
Rasouli, S.; Montazeri, M.; Mashayekhi, S.; Sadeghi-Soureh, S.; Dadashpour, M.; Mousazadeh, H.; Nobakht, A.; Zarghami, N.; Pilehvar-Soltanahmadi, Y. Synergistic anticancer effects of electrospun nanofiber-mediated codelivery of Curcumin and Chrysin: Possible application in prevention of breast cancer local recurrence. J. Drug Deliv. Sci. Technol., 2020, 55, 101402.
[http://dx.doi.org/10.1016/j.jddst.2019.101402]
[46]
Sedghi, R.; Gholami, M.; Shaabani, A.; Saber, M.; Niknejad, H. Preparation of novel chitosan derivative nanofibers for prevention of breast cancer recurrence. Eur. Polym. J., 2020, 123, 109421.
[http://dx.doi.org/10.1016/j.eurpolymj.2019.109421]
[47]
Sedghi, R.; Shaabani, A.; Mohammadi, Z.; Samadi, F.Y.; Isaei, E. Biocompatible electrospinning chitosan nanofibers: A novel delivery system with superior local cancer therapy. Carbohydr. Polym., 2017, 159, 1-10.
[http://dx.doi.org/10.1016/j.carbpol.2016.12.011] [PMID: 28038737]
[48]
Razmshoar, P; Bahrami, SH; Akbari, S Functional hydrophilic highly biodegradable PCL nanofibers through direct aminolysis of PAMAM dendrimer. Int. J. Polym. Mater. Polym. Biomater., 2020, 69, 1069-1080.
[49]
Sudakaran, S.V.; Venugopal, J.R.; Vijayakumar, G.P.; Abisegapriyan, S.; Grace, A.N.; Ramakrishna, S. Sequel of MgO nanoparticles in PLACL nanofibers for anti-cancer therapy in synergy with curcumin/β-cyclodextrin. Mater. Sci. Eng. C, 2017, 71, 620-628.
[http://dx.doi.org/10.1016/j.msec.2016.10.050] [PMID: 27987753]
[50]
Cheng, T.; Zhang, Z.; Shen, H.; Jian, Z.; Li, J.; Chen, Y.; Shen, Y.; Dai, X. Topically applicated curcumin/gelatin-blended nanofibrous mat inhibits pancreatic adenocarcinoma by increasing ROS production and endoplasmic reticulum stress mediated apoptosis. J. Nanobiotechnology, 2020, 18(1), 126.
[http://dx.doi.org/10.1186/s12951-020-00687-2] [PMID: 32891174]
[51]
Sampath, M.; Lakra, R.; Korrapati, P.; Sengottuvelan, B. Curcumin loaded poly (lactic-co-glycolic) acid nanofiber for the treatment of carcinoma. Colloids Surf. B Biointerfaces, 2014, 117, 128-134.
[http://dx.doi.org/10.1016/j.colsurfb.2014.02.020] [PMID: 24646452]
[52]
Balashanmugam, P.; Sucharithra, G. Efficacy of Biopolymeric PVA-AuNPs and PCL-curcumin loaded electrospun nanofibers anticancer activity against A431 skin cancer cell line. Mater. Today Commun., 2020, 2020, 101276.
[53]
Wang, C.; Ma, C.; Wu, Z.; Liang, H.; Yan, P.; Song, J.; Ma, N.; Zhao, Q. Enhanced bioavailability and anticancer effect of curcumin-loaded electrospun nanofiber: in vitro and in vivo study. Nanoscale Res. Lett., 2015, 10(1), 439.
[http://dx.doi.org/10.1186/s11671-015-1146-2] [PMID: 26573930]
[54]
Liu, J.; Liu, J.; Xu, H.; Zhang, Y.; Chu, L.; Liu, Q.; Song, N.; Yang, C. Novel tumor-targeting, self-assembling peptide nanofiber as a carrier for effective curcumin delivery. Int. J. Nanomedicine, 2014, 9, 197-207.
[PMID: 24399876]
[55]
Varshosaz, J.; Jajanian-Najafabadi, A.; Soleymani, A.; Khajavinia, A. Poly (butylene adipate-co-terephthalate) electrospun nanofibers loaded with 5-fluorouracil and curcumin in treatment of colorectal cancer cells. Polym. Test., 2018, 65, 217-230.
[http://dx.doi.org/10.1016/j.polymertesting.2017.11.020]
[56]
Xu, H.; Wang, T.; Yang, C.; Li, X.; Liu, G.; Yang, Z.; Singh, P.K.; Krishnan, S.; Ding, D. Supramolecular nanofibers of curcumin for highly amplified radiosensitization of colorectal cancers to ionizing radiation. Adv. Funct. Mater., 2018, 28(14), 1707140.
[http://dx.doi.org/10.1002/adfm.201707140]
[57]
Xie, M.; Fan, D.; Chen, Y.; Zhao, Z.; He, X.; Li, G.; Chen, A.; Wu, X.; Li, J.; Li, Z.; Hunt, J.A.; Li, Y.; Lan, P. An implantable and controlled drug-release silk fibroin nanofibrous matrix to advance the treatment of solid tumour cancers. Biomaterials, 2016, 103, 33-43.
[http://dx.doi.org/10.1016/j.biomaterials.2016.06.049] [PMID: 27376557]
[58]
Shehzad, A.; Qureshi, M.; Anwar, M.N.; Lee, Y.S. Multifunctional curcumin mediate multitherapeutic effects. J. Food Sci., 2017, 82(9), 2006-2015.
[http://dx.doi.org/10.1111/1750-3841.13793] [PMID: 28771714]
[59]
Choudhuri, T.; Pal, S.; Das, T.; Sa, G. Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at G2 phase of cell cycle in a p53-dependent manner. J. Biol. Chem., 2005, 280(20), 20059-20068.
[http://dx.doi.org/10.1074/jbc.M410670200] [PMID: 15738001]
[60]
Vallianou, N.G.; Evangelopoulos, A.; Schizas, N.; Kazazis, C. Potential anticancer properties and mechanisms of action of curcumin. Anticancer Res., 2015, 35(2), 645-651.
[PMID: 25667441]
[61]
Forouzanfar, F.; Barreto, G.; Majeed, M.; Sahebkar, A. Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach. Biofactors, 2019, 45(5), 631-640.
[http://dx.doi.org/10.1002/biof.1522] [PMID: 31136038]
[62]
Ghasemi, F.; Shafiee, M.; Banikazemi, Z.; Pourhanifeh, M.H.; Khanbabaei, H.; Shamshirian, A.; Amiri Moghadam, S.; ArefNezhad, R.; Sahebkar, A.; Avan, A.; Mirzaei, H. Curcumin inhibits NF-kB and Wnt/β-catenin pathways in cervical cancer cells. Pathol. Res. Pract., 2019, 215(10), 152556.
[http://dx.doi.org/10.1016/j.prp.2019.152556] [PMID: 31358480]
[63]
Hamzehzadeh, L.; Atkin, S.L.; Majeed, M.; Butler, A.E.; Sahebkar, A. The versatile role of curcumin in cancer prevention and treatment: A focus on PI3K/AKT pathway. J. Cell. Physiol., 2018, 233(10), 6530-6537.
[http://dx.doi.org/10.1002/jcp.26620] [PMID: 29693253]
[64]
Momtazi, A.A.; Shahabipour, F.; Khatibi, S.; Johnston, T.P.; Pirro, M.; Sahebkar, A. Curcumin as a MicroRNA regulator in cancer: A review. Rev. Physiol. Biochem. Pharmacol., 2016, 171, 1-38.
[http://dx.doi.org/10.1007/112_2016_3] [PMID: 27457236]
[65]
Mortezaee, K.; Salehi, E.; Mirtavoos-Mahyari, H.; Motevaseli, E.; Najafi, M.; Farhood, B.; Rosengren, R.J.; Sahebkar, A. Mechanisms of apoptosis modulation by curcumin: Implications for cancer therapy. J. Cell. Physiol., 2019, 234(8), 12537-12550.
[http://dx.doi.org/10.1002/jcp.28122] [PMID: 30623450]
[66]
Soflaei, S.S.; Momtazi-Borojeni, A.A.; Majeed, M.; Derosa, G.; Maffioli, P.; Sahebkar, A. Curcumin: A natural pan-HDAC inhibitor in cancer. Curr. Pharm. Des., 2018, 24(2), 123-129.
[http://dx.doi.org/10.2174/1381612823666171114165051] [PMID: 29141538]
[67]
Teymouri, M.; Pirro, M.; Johnston, T.P.; Sahebkar, A. Curcumin as a multifaceted compound against human papilloma virus infection and cervical cancers: A review of chemistry, cellular, molecular, and preclinical features. Biofactors, 2017, 43(3), 331-346.
[http://dx.doi.org/10.1002/biof.1344] [PMID: 27896883]

Rights & Permissions Print Cite
Article Metrics
37
3
World Chagas Disease
© 2024 Bentham Science Publishers | Privacy Policy