Heterotrimeric G Proteins Control Diverse Pathways of Transmembrane Signaling, a Base for Drug Discovery

Author(s): Yves Landry, J. P. Gies

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 2 , Issue 4 , 2002

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Heptahelical receptors are coupled to heterotrimeric GTP-binding proteins (G proteins) which transduce most signals through their a and bg subunits to effectors including adenylylcyclases, ion channels, phospholipases Cb, and phosphoinositide 3-kinases. The diversity of G proteins, their effectors and regulators (RGS proteins), supports the interest of these protein families as potential drug targets.

Keywords: heterotrimeric g protein, transmambrane signaling, heptahelical receptor, r g s protein

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Article Details

Year: 2002
Published on: 01 March, 2012
Page: [361 - 372]
Pages: 12
DOI: 10.2174/1389557023405945
Price: $65

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