Abstract
Molecular therapy is emerging as a potential strategy for the treatment of cardiovascular disease such as restenosis after angioplasty, vascular bypass graft occlusion, transplant coronary vasculopathy, homozygous familial hypercholesterolemia and cystic fibrosis, for which no known effective therapy exists. Molecular biology and pathophysiology of the cardiovascular system have started to emerge, and the time is ripe for the introduction of gene therapy to the management of cardiovascular disorders. In this review, we have focused on the future potential of oligonucleotide-based gene therapy for restenosis after angioplasty, which still remains an issue in the field of cardiovascular disease.
Keywords: gene therapy, antisense, ribozyme, cis-element decoy, restenosis, e2f
Current Drug Targets
Title: Oligonucleotide-Based Molecular Therapy for Restenosis after Angioplasty
Volume: 4 Issue: 8
Author(s): Motokuni Aoki, Ryuichi Morishita and Toshio Ogihara
Affiliation:
Keywords: gene therapy, antisense, ribozyme, cis-element decoy, restenosis, e2f
Abstract: Molecular therapy is emerging as a potential strategy for the treatment of cardiovascular disease such as restenosis after angioplasty, vascular bypass graft occlusion, transplant coronary vasculopathy, homozygous familial hypercholesterolemia and cystic fibrosis, for which no known effective therapy exists. Molecular biology and pathophysiology of the cardiovascular system have started to emerge, and the time is ripe for the introduction of gene therapy to the management of cardiovascular disorders. In this review, we have focused on the future potential of oligonucleotide-based gene therapy for restenosis after angioplasty, which still remains an issue in the field of cardiovascular disease.
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Cite this article as:
Aoki Motokuni, Morishita Ryuichi and Ogihara Toshio, Oligonucleotide-Based Molecular Therapy for Restenosis after Angioplasty, Current Drug Targets 2003; 4 (8) . https://dx.doi.org/10.2174/1389450033490830
DOI https://dx.doi.org/10.2174/1389450033490830 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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