Natural substances are known to have strong protective effects against neurodegenerative diseases. Among them,
phenolic compounds, especially flavonoids, come to the fore with their neuroprotective effects. Since quercetin, which is
found in many medicinal plants and foods, is also taken through diet, its physiological effects on humans are imperative.
Many studies have been published up to date on the neuroprotective properties of quercetin, a flavanol derivative. However,
there is no review published so far summarizing the effect of quercetin on the cholinesterase (ChE) enzymes related to the
cholinergic hypothesis, which is one of the pathological mechanisms of Alzheimer's disease (AD). However, ChE inhibitors
regardless of natural or synthetic play a vital role in the treatment of AD. Although the number of studies on the ChE
inhibitory effect of quercetin is limited, it deserves to be discussed in a review article. With this sensitivity, the
neuroprotective effect of quercetin against AD through ChE inhibition was scrutinized in the current review study. In
addition, studies on the bioavailability of quercetin and its capacity to cross the blood-brain barrier and how this capacity
and bioavailability can be increased were given. Generally, studies containing data published in recent years were obtained
from search engines such as PubMed, Scopus, and Medline and included herein.
Consequently, quercetin should not be considered as a fashionable natural compound and should be identified as a
promising compound, especially with increased bioavailability, for the treatment of AD.