Development and Biocompatibility Analysis of NBD Peptide Sustained- Release Microsphere Scaffold Nanoparticle SP-Sr-CaS/NBD

Author(s): Xue Li, Lei Wang, Changbing Wang, Caixia Tan, Xifaofang Liu, Yongzhan Zhu*

Journal Name: Current Drug Delivery

Volume 18 , Issue 4 , 2021


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Abstract:

Background: In clinical treatment, it is difficult to carry out effective bone tissue transplantation and anti-inflammatory treatment at the same time due to bone defects and osteomyelitis where the tissue is contaminated or infected. As a downstream target of TNF-α, NF-κB has an inhibition effect on the proliferation and differentiation of cells surrounding the lesion. As a negative effect, it leads to a reduction in bone growth and development.

Methods: In this study, the small molecule NBD polypeptide and bone conduction matrix Sr-CaS are microspheres, formed to prepare Sr-CaS, NBD drug-loaded sustained-release microspheres in order to achieve a Sr-CaS/NBD peptide drug-loaded sustained release microsphere scaffold material (SP-Sr-CaS/NBD). We prepared the microspheres and optimized the production process to obtain particles with stable morphological properties and sustained release properties.

Result: In vitro experiments demonstrated that SP-Sr-CaS/NBD could reduce TNF-α-induced cell growth inhibition, caspase-3 activity and NF-κB transcriptional activation as the function of continuous NBD peptide dosing regimen.

Conclusion: Also, the introduction of the Sr-CaS matrix potentiates microspheres to promote cell proliferation and provides a basis to become a promising 3D bone scaffold material in the future.

Keywords: NBD, PLGA, calcium sulfate, osteomyelitis, microsphere, scaffold materials.

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Article Details

VOLUME: 18
ISSUE: 4
Year: 2021
Published on: 16 November, 2020
Page: [433 - 445]
Pages: 13
DOI: 10.2174/1567201817999201116154935
Price: $65

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