Oceans can play a major role in supplying life-saving medicines to the world. Although considerable
progress has been made in finding new medicines from marine sources, great efforts are still
necessary to examine such molecules for clinical applications. Xyloketals are an important group of
natural products with various powerful and prominent bioactivities such as inhibition of acetylcholine
esterase, antioxidant activity, inhibition of L-calcium channels, radical-scavenging behavior, suppression
of cell proliferation, reduction of neonatal hypoxic-ischemic brain injury, etc. This review describes
the isolation and structural characterization of all xyloketal natural products giving major emphasis
on their bioactivity.