Oleamide in Ipomoea and Dillenia Species and Inflammatory Activity Investigated through Ion Channel Inhibition

Author(s): Unchaleeporn Ameamsri, Arunrat Chaveerach, Runglawan Sudmoon, Tawatchai Tanee*, Steve Peigneur, Jan Tytgat

Journal Name: Current Pharmaceutical Biotechnology

Volume 22 , Issue 2 , 2021

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Graphical Abstract:


Background: Oleamide is an essential substance for human health. So, the plants with high oleamide content are great sources for health care products.

Objective: This study is conducted to investigate the quality of oleamide in plants and test the bioactivity in the selected two studied species.

Methods: The three Ipomoea and five Dillenia species including Ipomoea alba, Ipomoea aquatica and Ipomoea pes-caprae, and Dillenia indica, Dillenia obovata, Dillenia ovata, Dillenia parviflora and Dillenia pentagyna were investigated for the quantity of oleamide by high-performance liquid chromatography. The biological activity test was conducted on the powder formulation of the chosen plants, Dillenia ovata and Dillenia parviflora at a ratio of 30:70, for anti-inflammatory activity ex vivo on a panel of molecular targets through ion channel inhibition including voltage-gated sodium channel, voltage-gated potassium channel, and the cardiac ion as human ether-a-go-go related gene.

Results: The results showed that the leaf extracts of I. aquatica and D. ovata gave the highest and subsequent oleamide quantity i.e. 7.52 and 5.17 mg/g, respectively. Out of the Dillenia formulation which contained various compounds, oleamide showed the highest percentages of inhibition at 8.0-20.0%, and 6.2-14.2% in voltage-gated sodium channel, and voltage-gated potassium channel which had slightly lower values than the oleamide standard, and no effect as 0.0% value inhibition in the cardiac ion channel.

Conclusion: The Dillenia formulation exhibits anti-inflammatory activity without affecting the heart. Accordingly, the three studied Ipomoea and three studied Dillenia species may be used for the same activity as a single component or formulation with effective solvent for disease treatments.

Keywords: Dillenia, High-Performance Liquid Chromatography (HPLC), Ipomoea, inflammatory activity, ion channel inhibition, oleamide.

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Article Details

Year: 2021
Published on: 07 June, 2020
Page: [254 - 261]
Pages: 8
DOI: 10.2174/1389201021666200607185250
Price: $65

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