Can Anti-Thyroid Antibodies Influence the Outcome of Primary Chronic Immune Thrombocytopenia in Children?

Author(s): Paola Giordano, Maurizio Delvecchio, Giuseppe Lassandro, Federica Valente, Valentina Palladino, Mariangela Chiarito, Malgorzata Wasniewska, Maria F. Faienza*.

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)

Volume 20 , Issue 3 , 2020

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Graphical Abstract:


Abstract:

Background: Immune thrombocytopenia (ITP) is an acquired immune mediated disorder characterized by isolated thrombocytopenia. Pediatric ITP patients can develop autoantibodies such as anti-thyroglobulin (TG) and anti-thyroperoxidase (TPO), even in the absence of clinical signs of autoimmune disease.

Objective: The purpose of this article is to provide a review about: 1) the prevalence of positivity of anti-thyroid antibodies (TPO and TG) in pediatric patients with chronic ITP; 2) the role of autoimmune thyroiditis on the outcome of chronic ITP.

Methods: The authors individually completed a review of the literature for this article. Retrospective and prospective clinical studies with pediatric cohorts were considered.

Results: From the analysis of data, we found 4 papers which included studies only on pediatric population, and which corresponded to selected criteria. Pediatric ITP patients have been shown to have a statistically significant prevalence of anti-thyroid antibodies over healthy controls (11.6-36% versus 1.2-1.3%). No correlation has been found between the platelet count and the prevalence of positive anti-thyroid antibodies at any time of the follow up.

Conclusion: The results of our bibliographic research demonstrated that: a) pediatric patients with chronic ITP tend to have a statistically significant prevalence of anti-thyroid antibodies positivity respect to general pediatric population; b) there are no clear data about the role of autoimmune thyroiditis as prognostic factor for chronic course of ITP in pediatric age.

Keywords: Immune thrombocytopenia, thyroid, autoimmunity, children, anti-thyroglobulin, anti-thyroperoxidase.

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Article Details

VOLUME: 20
ISSUE: 3
Year: 2020
Page: [351 - 355]
Pages: 5
DOI: 10.2174/1871530319666190905161347
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