Non-cirrhotic Portal Hypertension Associated with Didanosine and Streptococcus agalactiae Infection: A Case Report

Author(s): Vesna Turkulov, Maja Ruzic, Dajana Lendak, Daniela Maric, Snezana Brkic, Ludovico Abenavoli

Journal Name: Reviews on Recent Clinical Trials

Volume 11 , Issue 2 , 2016

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Graphical Abstract:


Background: Non-Cirrhotic Portal Hypertension (NCPH) is a rare but potentially fatal liver disorder described in patients treated with anti-retroviral therapy for Human Immunodeficiency Virus (HIV). In particular, the most important predisposing factor to its development has been identified as prolonged exposure to Didanosine (ddI). The clinical entity of NCPH is characterized by an increase in portal pressure due to pre- or intra-hepatic causes, in absence of liver cirrhosis. However, the exact pathogenesis remains poorly understood, and due to its rarity, the diagnosis is often delayed.

Objective: We herein report a case in which ddI administration, with concomitant spontaneous bacterial peritonitis by Streptococcus agalactiae, has induced NCPH in a HIV male patient.

Conclusion: NPCH should be suspected when HIV patient with an history of ddI treatment presents liver decompensation.

Keywords: Antiretroviral therapy, ascites, didanosine, human immunodeficiency virus, non-cirrhotic portal hypertension, Streptococcus agalactiae.

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Article Details

Year: 2016
Published on: 01 May, 2016
Page: [152 - 155]
Pages: 4
DOI: 10.2174/1574887111666160122095814

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