Computer-Aided Drug Discovery Methods: A Brief Introduction explores the cutting-edge field at the intersection of computational science and medicinal chemistry. This comprehensive volume navigates from foundational concepts to advanced methodologies, illuminating how computational tools accelerate the discovery of new therapeutics. Beginning with an overview of drug discovery principles, the book explains topics such as pharmacophore modeling, molecular dynamics simulations, and molecular docking. It discusses the application of density functional theory and the role of artificial intelligence in therapeutic development, showcasing successful case studies and innovations in COVID-19 research. Ideal for undergraduate and graduate students, as well as researchers in academia and industry, this book serves as a vital resource in understanding the complex landscape of modern drug discovery. It emphasizes the synergy between computational methods and experimental validation, shaping the future of pharmaceutical sciences toward more effective and targeted therapies.

The Roles and Responsibilities of Clinical Pharmacists in Hospital Settings is a comprehensive textbook designed to equip graduate pharmacy students and residents with the essential skills and knowledge needed for effective clinical pharmacy practice in hospitals. This book emphasizes the multidisciplinary nature of clinical pharmacy and the importance of adhering to international guidelines and standards. The book provides an overview of hospital pharmacy practice with an introduction to the essential requirements of a hospital environment, followed by a detailed exploration of clinical pharmacist roles across major medical subspecialties, including internal medicine, infectious diseases, intensive care, pediatrics, cardiology, and oncology. Key Features General and specialized Roles: Comprehensively covers different aspects of clinical pharmacology from basics to medical subspecialties Practical Insights: Offers practical tools, reference resources, and strategies for clinical pharmacy practice across different hospital departments. Advanced Practice: Guides readers from foundational knowledge to advanced clinical pharmacy practices, preparing them for specialized roles within hospital settings. Global Standards: Highlights the importance of multidisciplinary education and adherence to global clinical pharmacy standards. This textbook is an essential resource for pharmacy students, specialist assistants, and anyone pursuing a career in clinical pharmacy.

This book aims to fill research gaps in the search for chemotherapeutic and chemopreventive natural compounds. It includes a collection of detailed reviews focusing on bioactive compounds from plant sources that can be beneficial for cancer therapy. Topics covered include the role of antioxidants in cancer therapy, medicinal plants for cancer chemotherapeutics, bioactive compounds from marine plants, and a review of inhibiting nitric oxide reactions for preventing cancer. Chapters are contributed by researchers who have provided detailed lists and descriptions of the relevant plant sources, the compounds and the biochemical reactions. The book includes references for advanced reading. This book is intended as a reference for scholars and healthcare professionals studying natural medicines for cancer prevention and treatment.

This book provides a compressive overview of nanotechnology in modern drug discovery for students and researchers. The book starts with the fundamentals of nanotechnology followed by nanomaterials in pharmaceutical drug design, drug delivery applications, regulatory aspects, formulation and nanoparticle biotransformation. It provides a step by step guide through the drug development process while conveying information about the benefits of nanomaterials for therapy. The book concludes with perspective on the future of nanotechnology-based drug discovery, summarizing current knowledge on nanotherapeutics and translational medicine. Key Features - Explains the fundamentals of nanotechnology in drug discovery - Includes up-to-date information on modern nanopharmaceutical manufacturing, nanomaterials, and nanoparticle-based drug therapy - Practice questions for learners and a list of references for advanced readers for each chapter

Drug Addiction Mechanisms in the Brain explores the fascinating world of drug substances and their effects on the brain. This book provides a comprehensive overview of the ten major substances that contribute to drug addiction Information about each substance is presented in a specific chapter, shedding light on their biochemical mechanisms and physiological effects. From the stimulating effects of cocaine to the sedative properties of heroin, and the hallucinogenic experiences induced by LSD, the book takes the reader through the intricate pathways of addiction. Other substances covered in the book include alcohol, nicotine, MDMA, METH, morphine, ketamine, and fentanyl. Readers will gain an understanding about neurochemical alterations in the brain Anyone looking for interesting knowledge about the addictive nature of common drugs and their complex interplay with the brain will find this book informative.

Software and Programming Tools in Pharmaceutical Research is a detailed primer on the use for computer programs in the design and development of new drugs. Chapters offer information about different programs and computational techniques in pharmacology. The book will help readers to harness computer technologies in pharmaceutical investigations. Readers will also appreciate the pivotal role that software applications and programming tools play in revolutionizing the pharmaceutical industry. The book includes nine structured chapters, each addressing a critical aspect of pharmaceutical research and software utilization. From an introduction to pharmaceutical informatics and computational chemistry to advanced topics like molecular modeling, data mining, and high-throughput screening, this book covers a wide range of topics. Key Features: - Practical Insights: Presents practical knowledge on how to effectively utilize software tools in pharmaceutical research. - Interdisciplinary Approach: Bridges the gap between pharmaceutical science and computer science - Cutting-Edge Topics: Covers the latest advancements in computational drug development, including data analysis and visualization techniques, drug repurposing, pharmacokinetic modelling and screening. - Recommendations for Tools: Includes informative tables for software tools - Referenced content: Includes scientific references for advanced readers The book is an ideal primer for students and educators in pharmaceutical science and computational biology, providing a comprehensive foundation for this rapidly evolving field. It is also an essential resource for pharmaceutical researchers, scientists, and professionals looking to enhance their understanding of software tools and programming in drug development.

Unlock success in pharmaceutical exams with Objective Pharmaceutics: A Comprehensive Compilation of Questions and Answers for Pharmaceutics Exam Prep. This guide is meticulously crafted to tackle the challenges of pharmaceutics exams through a diverse range of questions. It covers multiple choice questions, concise one-liners, and true/false statements, mirroring the formats commonly found in drug inspector, pharmacist, GPAT, nursing exams, and more. Key Features: Exam-Ready Questions: Prepare for a variety of medical exams with more than 2000 carefully curated questions. Diverse Testing Formats: Master multiple choice, one-liner, and true/false questions for a well-rounded exam readiness. Broad Assessment: Tailored for drug inspectors, pharmacists, GPAT aspirants, and other medical professionals. Build Thinking Capabilities: Progress from simple to challenging questions, enhancing critical thinking skills. This thorough guide empowers you to learn the key topics in pharmaceutics and navigate the most challenging questions in your exam prep journey.

Biotechnology and Drug Development for Targeting Human Diseases is an insightful compendium on drug development technologies for professionals and students in biotechnology and pharmacology. This book meticulously explores the intersection of biotechnology with drug development, emphasizing its crucial role in creating new therapies for human disease. Central to the book is the innovative use of biotechnology in understanding and treating diseases. It begins with an exploration of multi-omics profiles, shedding light on disease mechanisms and drug development. Subsequent chapters explain in silico methods for drug design, the role of natural products in antimicrobial applications and wound healing, and the use of viruses as carriers in biotechnology. Key features of this reference include a blend of theoretical knowledge and practical insights, detailed analyses of molecular docking in drug discovery, the repurposing of drugs for various diseases, and the emerging field of omics technologies in drug interaction studies. Each chapter is comprehensive, offering current information backed by extensive references, making the book both a foundational and advanced resource.

The primary objective of this 4-volume book series is to educate PharmD students on the subject of medicinal chemistry. The book set serves as a reference guide to pharmacists on aspects of the chemical basis of drug action. Medicinal Chemistry of Drugs Affecting Cardiovascular and Endocrine Systems is the third volume of the series. This volume features 8 chapters focusing on a comprehensive account of drugs affecting both the cardiovascular system and the endocrine functions. The volume informs readers about the medicinal chemistry of relevant drugs, which includes the mechanism of drug action, detailed structure-activity relationships and metabolism. Topics covered include drugs that affect the renin-angiotensin system, calcium channel blockers, diuretics, hematological agents (anticoagulants, thrombolytic and antiplatelet agents), antidiabetics, antihistamines, proton pump inhibitors and therapeutic hormones. Each chapter also offers case studies and self-assessments to facilitate discussion and learning. The book equips students with a scientific foundation to competently evaluate, recommend and counsel patients and health care professionals regarding the safe, appropriate, and cost-effective use of medications. Students and teachers will also be able to integrate the knowledge presented in the book and apply medicinal chemistry concepts to understand the pharmacodynamics and pharmacokinetics of therapeutic agents in the body. The information offered by the book chapters will give readers a strong neuropharmacology knowledge base required for a practicing pharmacist.

The book summarizes the role of multiple enzyme targets and strategies to design and develop novel drug candidates for Alzheimer's disease (AD). Insights from researchers across the globe from diverse fields are presented in a thematic volume. The chapters highlight current information scientists have unraveled about the origin, pathogenesis and prevention of AD. The contributions consider both established and emerging drug targets viz. Tau proteins, TREM, and microglia. Topics covered in the book include multi-target anti-Alzheimer's agents, epigenetic modifications, and the role of specific proteins like TMP21 and Tau in AD. A section dedicated to pharmacological treatments discusses the significance of tubulin-modifying enzymes, memantine, and glutamate antagonists. Enzymatic targets for drug discovery are thoroughly examined, focusing on cholinesterase, secretases, and other enzymes. Additionally, the book explores innovative nano-carrier-based drug delivery methods, emphasizing the crucial role of nanotechnology in effective Alzheimer's treatment. The book aims to inform students and researchers in the field of neuroscience, medicine and pharmacology about current research and biochemical nuances of AD pathogenesis and enzymatic drug targeting strategies.