Microwave Assisted Synthesis of Chalcogenides

Author(s): Sabir Ahammed, Debasish Kundu, Nirmalya Mukherjee, Brindaban C. Ranu

Journal Name: Current Microwave Chemistry

Volume 4 , Issue 1 , 2017


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Abstract:

Background: The microwave reactor has been an important tool in organic synthesis. During last two decades microwave radiation has been successfully used in a variety of reactions including carbon- carbon and carbon-heteroatom bond formation. The application of microwave energy for carbonchalcogen bond formation leading to the synthesis of chalcogenides have been reported by various groups. Considering the importance of organo-chalocogenides in pharmaceutical industries this review is initiated to assemble these results in one article.

Methods: Microwave radiation has been applied for carbon-chalcogen bond formation producing a variety of diversely substituted chalocogenides.

Results: A variety of organo-sulfur, organo-selenium and organo-tellurium compounds have been synthesized starting from readily available and inexpensive starting materials quite efficiently. It was also demonstrated that microwave heating is superior to conventional heating in many reactions giving higher yield, clean product and shorter reaction time.

Conclusion: This review, in general highlights the microwave-assisted carbon-chalcogen bond formation leading to the synthesis of a variety of chalcogenides. It covers the recent developments on various types of reactions including C-H activation under microwave irradiation producing a variety of sulfides, selenides and tellurides. The prominent among them are Promazine, VX-745, a potent inhibitor with p38 activity, 8-arylsulfanyl adenine, a core structure present in several inhibitors of heat shock protein 90 (Hsp90) which is an attractive target in cancer and neurodegenerative diseases, and unsymmetrical diheteroaryl selenides and tellurides which are of much potential for pharmaceutical activity. We hope, this will be of much interest to a wide spectrum of chemists in academia and industry.

Keywords: Bond formation, carbon-hetero atom, chalcogenide, green chemistry, heterogeneous catalyst, microwave.

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Article Details

VOLUME: 4
ISSUE: 1
Year: 2017
Published on: 01 December, 2016
Page: [25 - 35]
Pages: 11
DOI: 10.2174/2213335602666150810204449
Price: $25

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