An Improved Method for the Synthesis of β-Aminocarbonyl and β-Aminonitrile Compounds using Indium (III) Trifluoromethanesulphonate in Glycerol under Microwave Irradiation

Title:An Improved Method for the Synthesis of β-Aminocarbonyl and β-Aminonitrile Compounds using Indium (III) Trifluoromethanesulphonate in Glycerol under Microwave Irradiation

Volume: 3 Issue: 1

Author(s): Monmi Saikia, Dibakar C. Deka and Sanjeeb Karmakar

Affiliation:

Keywords: Aza-michael, glycerol, microwave, β-aminocarbonyl, β-aminonitrile.

Abstract: An efficient and green protocol for the synthesis of β-aminocarbonyl and β-aminonitrile compounds has been developed. Near quantitative yield is achieved by mixing of a primary or a secondary amine with an α,β-unsaturated carbonyl compound under microwave irradiation in the presence of indium(III) triflate as the catalyst in glycerol as a green solvent. The reaction is simple, clean and complete within a few minutes and the product needs no purification.

Cite this article as:

Saikia Monmi, Deka C. Dibakar and Karmakar Sanjeeb, An Improved Method for the Synthesis of β-Aminocarbonyl and β-Aminonitrile Compounds using Indium (III) Trifluoromethanesulphonate in Glycerol under Microwave Irradiation, Current Microwave Chemistry 2016; 3 (1) . https://dx.doi.org/10.2174/2213335602666150505220420