A system of multiple organs integrated on a single chip or human on a chip (HUC) has a great potential
for drug discovery. Such a system helps to advance the fundamental understanding of diseases as well as
the complex interactions between cells, tissues and organs. HUC models will potentially overcome the shortcomings
of traditional animal models such as high cost, incompatibility with human physiology, the inability to
control and manipulate the microenvironment in vivo and the lack of efficacy. The matching length scale of biological
structures and micromachined components makes a microfluidic chip the ideal platform to investigate physiological
events. This paper presents an overview of the state of the art of the development of HUC. The paper also provides a perspective
on the integration of cell culture on a chip to create an ethical human model and to provide insights into the sensitivity
of different cell constructs on drugs.
Keywords: Cells, human on a chip, lab on a chip, microfluidics, organ on a chip.
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