Title:Phytochemical Analyses and Activity of Herbal Medicinal Plants of North- East India for Anti-Diabetic, Anti-Cancer and Anti-Tuberculosis and their Docking Studies
VOLUME: 15 ISSUE: 1
Author(s):Sivasubramanian Suhitha, Seenivasan Karthiga Devi, Krishnasamy Gunasekaran, H. Carehome Pakyntein, Atanu Bhattacharjee and Devadasan Velmurugan
Affiliation:Centre of Advanced Study in Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai -25, India.
Keywords:North east medicinal plants, Phytochemical, Jaintia hills, Activity prediction, Docking, Tuberculosis, Cancer, Diabetes.
Abstract:The traditional knowledge of medicinal plants that are in use by the indigenous Jaintia
tribes residing in few isolated pockets of North-East India is documented here. The present study was
carried out through the personal discussion with the president of the Jaintia Indigenous Herbal Medicine Association,
Dr.H.Carehome Pakyntein from Jowai, Meghalaya. The plants being used generation after generation by his family of
herbalists to cure ailments like tuberculosis, cancer and diabetes were selected for the present study. In order to scientifically
validate the use of these selected plants for the cure of selected diseases, phytochemical analyses, characterization
and molecular docking studies of some of the selected compounds from these plants have been carried out. The compounds
2-hydroxy-4-methoxy- Benzaldehyde from methanolic extract of Strophanthus Wallichii and DL tetrahydropalmatine
from Stephania Hernandifolia have been confirmed after determining their molecular structures, justifying the activity
of these two plants against TB and cancer, respectively. The present study covers the potentials of some of the medicinal
plants of North east India in curing common diseases due to which millions of people suffer and die. The presence
of certain compounds in these plants related to the cure of the diseases deserves further studies.
