Multicomponent 1,3-Dipolar Cycloaddition Reactions in the Construction of Hybrid Spiroheterocycles

Author(s): Natarajan Arumugam, Raju Suresh Kumar, Abdulrahman I. Almansour, Subbu Perumal

Journal Name: Current Organic Chemistry

Volume 17 , Issue 18 , 2013

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Spiroheterocyclic ring systems are attractive synthetic targets due to their interesting conformational features and their structural implications on their activity in biological systems. Consequently, a vast deal of research by synthetic organic as well as medicinal chemists pertains to the synthesis of these heterocycles employing diverse synthetic methodologies. Among them, one-pot multicomponent 1,3-cycloaddition reactions have emerged as preferred synthetic protocol in view of their convergence, atom economy, ecofriendliness, flexibility and facile automation. This review article focuses on the assembly of mono-, di- and multispiro heterocyclic hybrids via aforesaid synthetic methodologies with a variety of dipolarophiles.

Keywords: Multicomponent, 1, 3-Dipolar cycloadditions, Spiroheterocycles, Azomethine ylides and Nitrile oxides.

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Article Details

Year: 2013
Page: [1929 - 1956]
Pages: 28
DOI: 10.2174/13852728113179990091
Price: $65

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