Current Trends in the Use of Cationic Polymer Assemblies for siRNA and Plasmid DNA Delivery

Author(s): Gemma Navarro, Sara Movassaghian, Vladimir P. Torchilin

Journal Name: Pharmaceutical Nanotechnology

Volume 1 , Issue 3 , 2013

Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Gene therapy is a promising approach for disease prevention and therapy. Efficient gene delivery is an important factor limiting gene delivery. Due to the poor stability of nucleotide molecules in vivo, they require an association with delivery systems to overcome extracellular and intracellular barriers and allow access to the site of action. In this review, we discuss the challenges currently encountered in the delivery of DNA and RNAi-based therapies using the most common cationic polymer assemblies including polylysines, chitosan, polyethylenimines, dendrimers, cyclodextrins and illustrate with examples how chemical modification of cationic assemblies may contribute to their successful application in the clinic.

Keywords: Cationic assemblies, cationic polymers, complexes, DNA delivery, gene delivery, RNA interference, siRNA delivery.

open access plus

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2013
Published on: 24 July, 2013
Page: [165 - 183]
Pages: 19
DOI: 10.2174/22117385113019990003

Article Metrics

PDF: 55