New compounds with hydrophyllic esters of (-)-carinol were synthesized and evaluated as xanthine oxidase enzyme
inhibitors and antioxidants. Aliphatic esterfication of C-9,9'-OH groups of (-)-carinol resulted in lowering antioxidant
and xanthine oxidase inhibitory activities. However certain aromatic acyl esters considerably improved the xathine
oxidase inhibition. Aromatic esterification with electron withdrawing substitutions would preferred for improvement in
XOD inhibition while retaining radical scavenging activity, electron withdrawing substitution led to the loss of free radical
scavenging property and neutral substituents decrease the enzyme inhibitory potential.
Keywords: (-)-Carinol, Acyl derivatives, Xanthine oxidase inhibition, Free radical scavenging activity
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