Abstract
Shikimic acid, a natural compound is a key intermediate in the biosynthesis of amino acids. Consequently, this derivative is widely present in many plants and has interesting biological properties. But besides the pharmacological relevance of shikimic acid itself, it is also an intermediate in the synthesis of many drugs, being the most relevant the antiviral agent oseltamivir (TamifluTM). Here we present a short overview on recent natural, biotechnological and synthetical sources of shikimic acid, togheter with pharmacological applications of this compound and a selection of derivatives, including oseltamivir (TamifluTM).
Keywords: Shikimic acid, natural products, biotechnology, Oseltamivir (TamifluTM), neuraminidase inhibitors, verum, Escherichia coli, Illicium verum, shikimic acid, Citrobacter freundii
Mini-Reviews in Medicinal Chemistry
Title:A Short Overview on the Medicinal Chemistry of (—)-Shikimic Acid
Volume: 12 Issue: 14
Author(s): Amalia M. Estevez and Ramon J. Estevez
Affiliation:
Keywords: Shikimic acid, natural products, biotechnology, Oseltamivir (TamifluTM), neuraminidase inhibitors, verum, Escherichia coli, Illicium verum, shikimic acid, Citrobacter freundii
Abstract: Shikimic acid, a natural compound is a key intermediate in the biosynthesis of amino acids. Consequently, this derivative is widely present in many plants and has interesting biological properties. But besides the pharmacological relevance of shikimic acid itself, it is also an intermediate in the synthesis of many drugs, being the most relevant the antiviral agent oseltamivir (TamifluTM). Here we present a short overview on recent natural, biotechnological and synthetical sources of shikimic acid, togheter with pharmacological applications of this compound and a selection of derivatives, including oseltamivir (TamifluTM).
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Cite this article as:
M. Estevez Amalia and J. Estevez Ramon, A Short Overview on the Medicinal Chemistry of (—)-Shikimic Acid, Mini-Reviews in Medicinal Chemistry 2012; 12 (14) . https://dx.doi.org/10.2174/138955712803832735
DOI https://dx.doi.org/10.2174/138955712803832735 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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