Abstract
The cytotoxic activity of two bioactive molecules obtained from Croton species, caracasine acid (monomer) and micansinoic acid (dimer) belonging to the group of the seco-ent-kaurenes was evaluated against the prostate cancer cell line PC3 and human dermis fibroblasts (control cells). In addition, the combination of the monomer and dimer was realized with the antitumoral drugs taxol and adriamycin. The PC3 and normal cells were growth-inhibited in a dosedependent manner after exposure to both natural products. These two seco-ent-kaurenes exhibited practically the similar cytotoxic activity against human tumor cells but not to normal cells. The monomer and the dimer in combination with adriamycin and taxol respectively showed a synergistic effect on tumor cells, resulting that the combination of adriamycin with the monomer or dimer was more effective than with the taxol. Moreover, the combination of monomer and dimers showed a strong antagonistic effect.
Keywords: Prostate cancer, Croton micans, Seco-ent-kaurene, Monomer, Dimer, Combination index, Synergism, Tumor therapy.
Letters in Drug Design & Discovery
Title:Cytotoxic Effects of the Monomer and Dimer of 3, 4-seco-ent-kaurene from Croton Micans and their Interaction with Antitumoral Drugs on Cellular Line of Human Prostate Cancer
Volume: 10 Issue: 8
Author(s): Jennire Vivas, Felipe Sojo, Katiuska Chavez, Alírica I. Suarez and Francisco Arvelo
Affiliation:
Keywords: Prostate cancer, Croton micans, Seco-ent-kaurene, Monomer, Dimer, Combination index, Synergism, Tumor therapy.
Abstract: The cytotoxic activity of two bioactive molecules obtained from Croton species, caracasine acid (monomer) and micansinoic acid (dimer) belonging to the group of the seco-ent-kaurenes was evaluated against the prostate cancer cell line PC3 and human dermis fibroblasts (control cells). In addition, the combination of the monomer and dimer was realized with the antitumoral drugs taxol and adriamycin. The PC3 and normal cells were growth-inhibited in a dosedependent manner after exposure to both natural products. These two seco-ent-kaurenes exhibited practically the similar cytotoxic activity against human tumor cells but not to normal cells. The monomer and the dimer in combination with adriamycin and taxol respectively showed a synergistic effect on tumor cells, resulting that the combination of adriamycin with the monomer or dimer was more effective than with the taxol. Moreover, the combination of monomer and dimers showed a strong antagonistic effect.
Export Options
About this article
Cite this article as:
Vivas Jennire, Sojo Felipe, Chavez Katiuska, Suarez I. Alírica and Arvelo Francisco, Cytotoxic Effects of the Monomer and Dimer of 3, 4-seco-ent-kaurene from Croton Micans and their Interaction with Antitumoral Drugs on Cellular Line of Human Prostate Cancer, Letters in Drug Design & Discovery 2013; 10 (8) . https://dx.doi.org/10.2174/15701808113109990021
DOI https://dx.doi.org/10.2174/15701808113109990021 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Interactions between Transporters and Herbal Medicines/Drugs: A Focus on Hepatoprotective Compounds
Current Drug Metabolism A Review on Designing Poly (Lactic-co-glycolic Acid) Nanoparticles as Drug Delivery Systems
Pharmaceutical Nanotechnology The Current WHO Classification of Tumours of the Central Nervous System: Histopathology and Additional Diagnostic Methods
Current Medical Imaging Possibilities of Two-Dimensional Gel Electrophoresis in the Understanding of Human Disease
Current Proteomics Progress in Imaging Agents of Cell Apoptosis
Anti-Cancer Agents in Medicinal Chemistry Regulation of Autophagy by Sphingolipids
Anti-Cancer Agents in Medicinal Chemistry Iron Oxide Nanoparticles Synthesized Via Green Tea Extract for Doxorubicin Delivery
Current Nanoscience Subject Index To Volume 1
Recent Patents on Anti-Cancer Drug Discovery Improved Candidate Biomarker Detection Based on Mass Spectrometry Data Using the Hilbert-Huang Transform
Protein & Peptide Letters Cancer “Stemness”- Regulating MicroRNAs: Role, Mechanisms and Therapeutic Potential
Current Drug Targets Botanical Therapeutics (Part II): Antimicrobial and In Vitro Anticancer Activity against MCF7 Human Breast Cancer Cells of Chamomile, Parsley and Celery Alcoholic Extracts
Anti-Cancer Agents in Medicinal Chemistry Patent Selections
Recent Patents on Food, Nutrition & Agriculture FoxO Transcription Factors and Regenerative Pathways in Diabetes Mellitus
Current Neurovascular Research Metallothioneins, Ageing and Cellular Senescence: A Future Therapeutic Target
Current Pharmaceutical Design Multi-Target Inhibitors for Proteins Associated with Alzheimer: In Silico Discovery using Fragment-Based Descriptors
Current Alzheimer Research Effect of DNA Repair Deficiencies on the Cytotoxicity of Drugs Used in Cancer Therapy - A Review
Current Medicinal Chemistry Delta Np63 alpha – Responsive microRNA Modulate the Expression of Metabolic Enzymes
Current Pharmaceutical Biotechnology Lipoxygenase Inhibitors as Cancer Chemopreventives: Discovery, Recent Developments and Future Perspectives
Current Medicinal Chemistry 3T Diffusion Weighted MR Imaging in Diagnosing Extrahepatic Cholangiocarcinoma
Current Medical Imaging The ATP-driven Hsp60 Machinery: Biological and Clinical Implications
Current Immunology Reviews (Discontinued)