Experimental, Theoretical and Biological Activity of a Triazonine- Derivative on Left Ventricular Pressure

Title:Experimental, Theoretical and Biological Activity of a Triazonine- Derivative on Left Ventricular Pressure

Volume: 14 Issue: 2

Author(s): Lauro Figueroa-Valverde, Maria Lopez-Ramos, Marcela Rosas-Nexticapa, Socorro Herrera-Meza, Francisco Diaz-Cedillo, Elodia Garcia-Cervera, Eduardo Pool-Gomez, Tania Garcia-Camacho and Angel Aguilar-Villarino

Affiliation:

Keywords: Adrenosterone, androgen receptor, benzamide, ethylenediamine, triazonine derivative, ventricular pressure

Abstract: Background: There are data indicating that several azonine-derivatives may exert effects on some biological systems; however, there is very low information on the biological activity induced by these compounds on left ventricular pressure.

Objective: The aim of this study was to synthesize and evaluate the biological activity of new triazoninederivative on left ventricular pressure.

Material and Methods: The first stage involved: 1) preparation of two azepine-benzamide derivatives (Z or E) by reaction of the nitrobenzoyl azide with adrenosterone; and 2) reaction of (Z)-azepine-benzamide derivative with ethylenediamine to form the triazonine derivative. The structure of compounds was confirmed by spectroscopy and spectrometry data. The second stage involved the biologic activity on left ventricular pressure was evaluated in a model of rat heart isolated. In addition, some physicochemical parameters were evaluated to characterize the possible molecules involved in its effect.

Results: The results showed that only the triazonine increased left ventricular pressure via androgen receptor.

Conclusions: In conclusion, this phenomenon is conditioned by the functional groups involved in the chemical structure of triazonine derivative and their interaction with residues of amino acids involved on the androgen receptor surface.

Cite this article as:

Figueroa-Valverde Lauro, Lopez-Ramos Maria, Rosas-Nexticapa Marcela, Herrera-Meza Socorro, Diaz-Cedillo Francisco, Garcia-Cervera Elodia, Pool-Gomez Eduardo, Garcia-Camacho Tania and Aguilar-Villarino Angel, Experimental, Theoretical and Biological Activity of a Triazonine- Derivative on Left Ventricular Pressure, Cardiovascular & Hematological Agents in Medicinal Chemistry 2016; 14 (2) . https://dx.doi.org/10.2174/1871525715666161123115308

DOI https://dx.doi.org/10.2174/1871525715666161123115308	Print ISSN 1871-5257
Publisher Name Bentham Science Publisher	Online ISSN 1875-6182