Abstract
Symmetrical peptide GYDTQAIVENNESTEYG (WT, Wild Type) identical to 35-51 aminoacid residues of human alpha-lactalbumin (HLA) and peptide GYDTQTVVNNNGHTDYG (ID, IDeal symmetry) homologous to betadomain of mammalian alpha-lactalbumins can form amyloid-like fibrils in conditions required for fibrillogenesis of HLA. The latter peptide can also form fibrils in deionized water. Fibrils formed by these peptides can cause forming of HLA amyloid-like aggregates in physiological conditions. These results provide an evidence for presence of amyloidogenic determinant in beta-domain of alpha-lactalbumin. Thus, symmetry in the primary structure may play the role in fibrillogenesis of proteins.
Keywords: alpha-lactalbumin, fibrillogenesis, gydtqaivennesteyg, gydtqtvvnnnghtdyg, symmetry, atomic force microscopy
Protein & Peptide Letters
Title: Atomic Force Microscopy Study of Peptides Homologous to Beta-Domain of Alpha-Lactalbumins
Volume: 14 Issue: 5
Author(s): V. V. Egorov, K. V. Solovyov, N. A. Grudinina, D. V. Lebedev, V. V. Isaev-Ivanov, O. I. Kiselev and M. M. Shawlovsky
Affiliation:
Keywords: alpha-lactalbumin, fibrillogenesis, gydtqaivennesteyg, gydtqtvvnnnghtdyg, symmetry, atomic force microscopy
Abstract: Symmetrical peptide GYDTQAIVENNESTEYG (WT, Wild Type) identical to 35-51 aminoacid residues of human alpha-lactalbumin (HLA) and peptide GYDTQTVVNNNGHTDYG (ID, IDeal symmetry) homologous to betadomain of mammalian alpha-lactalbumins can form amyloid-like fibrils in conditions required for fibrillogenesis of HLA. The latter peptide can also form fibrils in deionized water. Fibrils formed by these peptides can cause forming of HLA amyloid-like aggregates in physiological conditions. These results provide an evidence for presence of amyloidogenic determinant in beta-domain of alpha-lactalbumin. Thus, symmetry in the primary structure may play the role in fibrillogenesis of proteins.
Export Options
About this article
Cite this article as:
Egorov V. V., Solovyov V. K., Grudinina A. N., Lebedev V. D., Isaev-Ivanov V. V., Kiselev I. O. and Shawlovsky M. M., Atomic Force Microscopy Study of Peptides Homologous to Beta-Domain of Alpha-Lactalbumins, Protein & Peptide Letters 2007; 14 (5) . https://dx.doi.org/10.2174/092986607780782858
DOI https://dx.doi.org/10.2174/092986607780782858 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
β-estradiol Induces Mitochondrial Apoptosis in Cervical Cancer through the Suppression of AKT/NF-κB Signaling Pathway
Recent Patents on Anti-Cancer Drug Discovery Estrogen Receptor Expression and its Relevant Signaling Pathway in Prostate Cancer: A Target of Therapy
Current Molecular Pharmacology Investigation of In Vitro Iontophoresis Facilitated Transdermal Delivery of Glycine
Current Drug Delivery Type 2 Diabetes Mellitus and Alzheimer’s Disease: Bridging the Pathophysiology and Management
Current Pharmaceutical Design Nucleic Acid Aptamers: Clinical Applications and Promising New Horizons
Current Medicinal Chemistry Perivascular Adipose Tissue as an Endocrine Organ: The Role of Statins
Current Pharmaceutical Design The Impact of Infection on the Incidence of Autoimmune Disease
Current Topics in Medicinal Chemistry Impact of SGLT Inhibitors on Multiple Organ Defects in Diabetes
Current Diabetes Reviews Management of Type 2 Diabetes: More Evidence is Required to Address the Clinical and Contextual Facets
Current Diabetes Reviews Potential of Gentiana lutea for the Treatment of Obesity-associated Diseases
Current Pharmaceutical Design CPP-mediated Protein Delivery in a Noncovalent Form: Proof-of-Concept for Percutaneous and Intranasal Delivery
Protein & Peptide Letters Glycogen Synthase Kinase-β3 in Ischemic Neuronal Death
Current Neurovascular Research Neuroprotective Effects of Lithium - Pointing out Protein Phosphatases as Drug Targets?
Current Medicinal Chemistry - Central Nervous System Agents Circulating Levels of Soluble Angiogenic Factors in Multiple Myeloma: Correlation with Parameters of Disease Activity and Prognosis
Current Angiogenesis (Discontinued) Automated System for Referral of Cotton-Wool Spots
Current Diabetes Reviews Crocetin Attenuates Spatial Learning Dysfunction and Hippocampal Injury in a Model of Vascular Dementia
Current Neurovascular Research The Pharmacological Pathways of GnRH Mediating the Inhibition of Mammary Tumours: Implications in Humans and Domestic Animals
Current Medicinal Chemistry mGlu2/3 Agonist-Induced Hyperthermia: An In Vivo Assay for Detection of mGlu2/3 Receptor Antagonism and its Relation to Antidepressant-Like Efficacy in Mice
CNS & Neurological Disorders - Drug Targets Compound Libraries: Recent Advances and Their Applications in Drug Discovery
Current Drug Discovery Technologies Syntheses and Effect of Bombesin-Fragment6-14 and its Four Analogues on Food Intake in Rats
Current Pharmaceutical Biotechnology