Abstract
The research presented in this paper discusses the potential of iontophoresis facilitated transdermal delivery of glycine. Iontophoresis has been widely investigated as a noninvasive transdermal drug delivery system. Iontophoresis is the use of a low electric current to carry ionized as well as unionized drug molecules across tissues (like skin) in a noninvasive technique. In the present paper, a custom made low cost, battery powered, portable transdermal iontophoretic system has been investigated for the various parameters of transdermal iontophoretic drug delivery namely drug density in donor formulation, current density, current profile, presence of competitive ions and type of electrode material. In vitro release studies of glycine, as a drug, were done using a modified Franz type glass diffusion cell through excised mouse skin. Factors affecting the delivery of glycine (a non-essential amino acid used to treat schizophrenia, anxiety, insomnia, hypoglycemia etc.) by iontophoresis include concentration of glycine in donor solution, ionic strength of donor solution, density of applied current & its aspect ratio. The change in frequency and electrode type (Ag/AgCl & stainless steel) did not have any significant effect on glycine delivery. In conclusion it could be stated that it is possible to achieve appreciable control over the transdermal delivery of glycine by the low-cost portable iontophoretic drug delivery system developed.
Keywords: Glycine, iontophoresis, transdermal drug delivery, iontophoretic device
Current Drug Delivery
Title: Investigation of In Vitro Iontophoresis Facilitated Transdermal Delivery of Glycine
Volume: 6 Issue: 2
Author(s): Rajdeep Dasgupta, Ajit K. Banthia and D. N. Tibarewala
Affiliation:
Keywords: Glycine, iontophoresis, transdermal drug delivery, iontophoretic device
Abstract: The research presented in this paper discusses the potential of iontophoresis facilitated transdermal delivery of glycine. Iontophoresis has been widely investigated as a noninvasive transdermal drug delivery system. Iontophoresis is the use of a low electric current to carry ionized as well as unionized drug molecules across tissues (like skin) in a noninvasive technique. In the present paper, a custom made low cost, battery powered, portable transdermal iontophoretic system has been investigated for the various parameters of transdermal iontophoretic drug delivery namely drug density in donor formulation, current density, current profile, presence of competitive ions and type of electrode material. In vitro release studies of glycine, as a drug, were done using a modified Franz type glass diffusion cell through excised mouse skin. Factors affecting the delivery of glycine (a non-essential amino acid used to treat schizophrenia, anxiety, insomnia, hypoglycemia etc.) by iontophoresis include concentration of glycine in donor solution, ionic strength of donor solution, density of applied current & its aspect ratio. The change in frequency and electrode type (Ag/AgCl & stainless steel) did not have any significant effect on glycine delivery. In conclusion it could be stated that it is possible to achieve appreciable control over the transdermal delivery of glycine by the low-cost portable iontophoretic drug delivery system developed.
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Cite this article as:
Dasgupta Rajdeep, Banthia K. Ajit and Tibarewala N. D., Investigation of In Vitro Iontophoresis Facilitated Transdermal Delivery of Glycine, Current Drug Delivery 2009; 6 (2) . https://dx.doi.org/10.2174/156720109787846207
DOI https://dx.doi.org/10.2174/156720109787846207 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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