Abstract
Peptides derived from tumor associated antigens can be utilized to elicit a therapeutically effective immune response against melanoma in experimental models. However, patient vaccination with peptides - although it is often followed by the induction of melanoma- specific T lymphocytes - is rarely associated with tumor response of clinical relevance. In this review I summarize the principles of peptide design as well as the results so far obtained in the clinical setting while treating cutaneous melanoma by means of this active immunotherapy strategy. I also discuss some immunological and methodological issues that might be helpful for the successful development of peptide-based vaccines.
Keywords: Peptide, melanoma, therapy, immunotherapy, vaccine, diagnosis, vaccination, tumor, T lymphocytes, carcinomas
Current Pharmaceutical Design
Title: Peptides in Melanoma Therapy
Volume: 18 Issue: 6
Author(s): Simone Mocellin
Affiliation:
Keywords: Peptide, melanoma, therapy, immunotherapy, vaccine, diagnosis, vaccination, tumor, T lymphocytes, carcinomas
Abstract: Peptides derived from tumor associated antigens can be utilized to elicit a therapeutically effective immune response against melanoma in experimental models. However, patient vaccination with peptides - although it is often followed by the induction of melanoma- specific T lymphocytes - is rarely associated with tumor response of clinical relevance. In this review I summarize the principles of peptide design as well as the results so far obtained in the clinical setting while treating cutaneous melanoma by means of this active immunotherapy strategy. I also discuss some immunological and methodological issues that might be helpful for the successful development of peptide-based vaccines.
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Cite this article as:
Mocellin Simone, Peptides in Melanoma Therapy, Current Pharmaceutical Design 2012; 18 (6) . https://dx.doi.org/10.2174/138161212799277734
DOI https://dx.doi.org/10.2174/138161212799277734 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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