Abstract
In the vascular wall of large arteries, cellular and humoral immune responses are elicited as a consequence of diverse noxious stimuli within subendothelial space, which further derives in endothelial dysfunction, the accumulation of lipids and formation of the atheromatous plaque. Monocytes, macrophages, T cells, endothelial cells and smooth muscular cells are all players in this inflammatory-atherosclerotic process, which is not only genetically regulated but also influenced by environmental factors. In this review, the summary of genetic variants in major immune mediators associated with the evolution of atherosclerosis is presented.
Keywords: Atherosclerosis, genetic polymorphisms, inflammation, cytokines
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Genetic Polymorphisms of Inflammatory Mediators in Atherosclerosis
Volume: 7 Issue: 3
Author(s): Ana Z. Fernandez
Affiliation:
Keywords: Atherosclerosis, genetic polymorphisms, inflammation, cytokines
Abstract: In the vascular wall of large arteries, cellular and humoral immune responses are elicited as a consequence of diverse noxious stimuli within subendothelial space, which further derives in endothelial dysfunction, the accumulation of lipids and formation of the atheromatous plaque. Monocytes, macrophages, T cells, endothelial cells and smooth muscular cells are all players in this inflammatory-atherosclerotic process, which is not only genetically regulated but also influenced by environmental factors. In this review, the summary of genetic variants in major immune mediators associated with the evolution of atherosclerosis is presented.
Export Options
About this article
Cite this article as:
Fernandez Z. Ana, Genetic Polymorphisms of Inflammatory Mediators in Atherosclerosis, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2008; 7 (3) . https://dx.doi.org/10.2174/187152308785699272
DOI https://dx.doi.org/10.2174/187152308785699272 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Natural Product-Derived Small Molecule Activators of Hypoxia-Inducible Factor-1 (HIF-1)
Current Pharmaceutical Design Cholinergic Receptors as Target for Cancer Therapy in a Systems Medicine Perspective
Current Molecular Medicine Strategies for Targeting Lentiviral Vectors
Current Gene Therapy Endocrinology and Immunology of Obesity, Obesity Vaccines
Current Clinical Pharmacology Possible Pathways of Hepatotoxicity Caused by Chemical Agents
Current Drug Metabolism Probiotics Against Viruses; COVID-19 is a Paper Tiger: A Systematic Review
Endocrine, Metabolic & Immune Disorders - Drug Targets Natural and Nanotechnology Based Treatment: An Alternative Approach to Psoriasis
Current Nanomedicine Cardiovascular and Metabolic Effects of Ghrelin
Current Diabetes Reviews subject Index To Volume 1
Current Medicinal Chemistry - Central Nervous System Agents Transferrin and the Transferrin Receptor: Of Magic Bullets and Other Concerns
Inflammation & Allergy - Drug Targets (Discontinued) A Review of the Ethnopharmacology, Phytochemistry and Pharmacology of Plants of the Maytenus Genus
Current Pharmaceutical Design Diet and Heart Health: Moderate Wine Drinking Strengthens the Cardioprotective Effects of Fish Consumption
Current Pharmaceutical Biotechnology Receptor for Advanced Glycation End Products (RAGE): A Novel Therapeutic Target for Diabetic Vascular Complication
Current Pharmaceutical Design Antidiabetic and Renoprotective Effects of Ethyl Acetate Fraction of <i>Mimosa pudica</i> Linn. Leaves Extract in Streptozotocin-Induced Diabetic Mice
Current Bioactive Compounds Pharmacogenetics and Anaesthesiology
Current Pharmacogenomics Cardiovascular Complications of HIV Infection and Treatment
Cardiovascular & Hematological Agents in Medicinal Chemistry Synergistic Activation of Leukocytes by Bacterial Chemoattractants: Potential Drug Targets
Endocrine, Metabolic & Immune Disorders - Drug Targets Targeting Transcription: A New Concept of Anti-Inflammatory Therapy of Airway Diseases
Current Drug Targets Small-Molecule CSF1R Inhibitors as Anticancer Agents
Current Medicinal Chemistry Interaction between Thienopyridines and Proton Pump Inhibitors
Cardiovascular & Hematological Disorders-Drug Targets