Abstract
Altered cellular production of reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) is a ubiquitous feature of human disease. Vascular oxidative stress is a unifying area of research in atherosclerosis and aging. While elevated levels of ROS, especially oxygen radicals (O2 -·) and hydrogen peroxide (H2O2), induce cellular apoptosis, low levels play an important role in cell signaling [1,2]. Reactive species from a variety of sources further play an important role in plaque disruption partly through lipid oxidation, low-density lipoprotein oxidation nitration, and signaling [3- 6].
Keywords: NADPH Oxidase, dihydroethidium, superoxide dismutase, Lipoxygenase, xanthine oxidase
Current Drug Targets
Title: Oxidative Stress as a Regulator of Murine Atherosclerosis
Volume: 8 Issue: 12
Author(s): Tzung Hsiai and Judith A. Berliner
Affiliation:
Keywords: NADPH Oxidase, dihydroethidium, superoxide dismutase, Lipoxygenase, xanthine oxidase
Abstract: Altered cellular production of reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) is a ubiquitous feature of human disease. Vascular oxidative stress is a unifying area of research in atherosclerosis and aging. While elevated levels of ROS, especially oxygen radicals (O2 -·) and hydrogen peroxide (H2O2), induce cellular apoptosis, low levels play an important role in cell signaling [1,2]. Reactive species from a variety of sources further play an important role in plaque disruption partly through lipid oxidation, low-density lipoprotein oxidation nitration, and signaling [3- 6].
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Cite this article as:
Hsiai Tzung and Berliner A. Judith, Oxidative Stress as a Regulator of Murine Atherosclerosis, Current Drug Targets 2007; 8 (12) . https://dx.doi.org/10.2174/138945007783220678
DOI https://dx.doi.org/10.2174/138945007783220678 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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