Microwave Assisted Synthesis and Antimicrobial Activity Evaluation of New Heterofunctionalized Norfloxacine Derivatives

Title:Microwave Assisted Synthesis and Antimicrobial Activity Evaluation of New Heterofunctionalized Norfloxacine Derivatives

Volume: 13 Issue: 10

Author(s): Meltem Mentese, Serpil Demirci, Serap B. Ozdemir, Ahmet Demirbas, Serdar Ulker and Neslihan Demirbas

Affiliation:

Keywords: Antimicrobial activity, mannich reaction, norfloxacine, piperazine, 1, 2, 4-triazole.

Abstract: The synthesis of new hybrid compounds containing several heterocyclic groups namely norfloxacine, 1,2,4-triazole, 1,3,4-oxadiazole, piperazine, morpholine, thiomorpholine, 1,3,4- thiadiazole etc. was performed by conventional and successfully optimized microwave assisted techniques. The effect of acid catalyst on one pot tricomponent Mannich reaction was investigated as well. The structures of newly synthesized compounds were eluciated on the basis of spectroscopic techniques. Also, the synthesized compounds were screened for their antimicrobial activities and most of them were found to possess good-moderate antimicrobial activity.

Cite this article as:

Mentese Meltem, Demirci Serpil, Ozdemir B. Serap, Demirbas Ahmet, Ulker Serdar and Demirbas Neslihan, Microwave Assisted Synthesis and Antimicrobial Activity Evaluation of New Heterofunctionalized Norfloxacine Derivatives, Letters in Drug Design & Discovery 2016; 13 (10) . https://dx.doi.org/10.2174/1570180813666160712222922