Abstract
A new series of 2,3-disubstituted thiazolidin-4-ones were synthesized from the appropriate amines, substituted aldehyde, and mercaptoacetic acid in the presence of DCC in anhydrous THF by microwave irradiation. The title compounds were investigated for their anticonvulsant activity. Among the test compounds, compound 2-(4- bromophenyl)-2-methylthiazolidin-4-one-3-isonicotinamide (8) emerged as most active compound of the series and it is moderately more potent than the reference standard diazepam.
Keywords: Thiazolidinone, Anti-convulsant activity. Microwave-irradiation, AED, Epilepsy, mercapto acid, DCC, microwave irradiation, AED, anti-inflammatory, cholerectic, anti-HIV, MCRs, Thomas Hoover melting point, FT-NMR spectrometer
Letters in Drug Design & Discovery
Title:2,3-Disubtituted Thiazolidin-4-ones: Novel Class of Anticonvulsant Agents
Volume: 9 Issue: 7
Author(s): M. Senthilraja, V. Alagarsamy and V. Raja Solomon
Affiliation:
Keywords: Thiazolidinone, Anti-convulsant activity. Microwave-irradiation, AED, Epilepsy, mercapto acid, DCC, microwave irradiation, AED, anti-inflammatory, cholerectic, anti-HIV, MCRs, Thomas Hoover melting point, FT-NMR spectrometer
Abstract: A new series of 2,3-disubstituted thiazolidin-4-ones were synthesized from the appropriate amines, substituted aldehyde, and mercaptoacetic acid in the presence of DCC in anhydrous THF by microwave irradiation. The title compounds were investigated for their anticonvulsant activity. Among the test compounds, compound 2-(4- bromophenyl)-2-methylthiazolidin-4-one-3-isonicotinamide (8) emerged as most active compound of the series and it is moderately more potent than the reference standard diazepam.
Export Options
About this article
Cite this article as:
Senthilraja M., Alagarsamy V. and Raja Solomon V., 2,3-Disubtituted Thiazolidin-4-ones: Novel Class of Anticonvulsant Agents, Letters in Drug Design & Discovery 2012; 9 (7) . https://dx.doi.org/10.2174/157018012801319517
DOI https://dx.doi.org/10.2174/157018012801319517 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Homocysteine Level and Mechanisms of Injury in Parkinson's Disease as Related to MTHFR, MTR, and MTHFD1 Genes Polymorphisms and LDopa Treatment
Current Genomics Adenosine and the Auditory System
Current Neuropharmacology Repositioning of Drugs in Cardiometabolic Disorders: Importance and Current Scenario
Current Topics in Medicinal Chemistry Endocannabinoids in the Central Nervous System: From Neuronal Networks to Behavior
Current Drug Targets - CNS & Neurological Disorders Structure-to-function Relationship of Carbohydrates in the Mechanism of Lysosomal Storage Disorders (LSDs)
Current Organic Chemistry Atypical GTPases as Drug Targets
Anti-Cancer Agents in Medicinal Chemistry Davunetide: Peptide Therapeutic in Neurological Disorders
Current Medicinal Chemistry Promising Polymeric Drug Carriers for Local Delivery: The Case of <i>in situ</i> Gels
Current Drug Delivery Nanotubes at Neural and Immune Synapses
Current Medicinal Chemistry Drug Repositioning: A Unique Approach to Refurbish Drug Discovery
Current Drug Discovery Technologies Current and Promising Therapies in Autosomal Recessive Ataxias
CNS & Neurological Disorders - Drug Targets MiR-125a-5p Alleviates Dysfunction and Inflammation of Pentylenetetrazol- induced Epilepsy Through Targeting Calmodulin-dependent Protein Kinase IV (CAMK4)
Current Neurovascular Research Recent Advances in Epilepsy
Current Neuropharmacology Valproate Induced Acute Pancreatitis - A Unique Case Report
Current Drug Safety Monitoring Antiepileptic Drugs: A Level-Headed Approach
Current Neuropharmacology Glutamate Carboxypeptidase II in Diagnosis and Treatment of Neurologic Disorders and Prostate Cancer
Current Medicinal Chemistry Importance of ABC Transporters in Drug Development
Current Pharmaceutical Design New Insights in Drug-Induced Mitochondrial Toxicity
Current Pharmaceutical Design Neurological Disorders in Mice Lacking Glycogenes that are Mainly Expressed in Brain
CNS & Neurological Disorders - Drug Targets Recent Patents on Epilepsy Genetics
Recent Patents on DNA & Gene Sequences