Abstract
The review provides a summary of synthetic approaches to and medicinal applications of N-aryl-C-nitroazoles. This broad chemical family delivered numerous practical applications in the areas other than pharmaceuticals. This is most likely due to a common stigma associated with nitroheterocycles implying their inherent toxicity. Therefore, the research literature appears to be lacking in medicinal chemistry reports related to this class of compounds. However, despite this notion, the nitroheterocycles have enjoyed a marked renaissance in the last years, particularly, in antimicrobial area. Therefore, an attempt to summarize, within a single review article, the medicinal applications and methods of synthesis has been undertaken.
Keywords: ANRORC, aromatic nucleophilic substitution, metal-catalyzed, N-arylation, nitroazoles.
Mini-Reviews in Medicinal Chemistry
Title:Synthesis and Medicinal Applications of N-Aryl-C-nitroazoles
Volume: 18 Issue: 20
Author(s): Sergey S. Chuprun, Grigory Kantin and Mikhail Krasavin*
Affiliation:
- Saint Petersburg State University, St. Petersburg 199034,Russian Federation
Keywords: ANRORC, aromatic nucleophilic substitution, metal-catalyzed, N-arylation, nitroazoles.
Abstract: The review provides a summary of synthetic approaches to and medicinal applications of N-aryl-C-nitroazoles. This broad chemical family delivered numerous practical applications in the areas other than pharmaceuticals. This is most likely due to a common stigma associated with nitroheterocycles implying their inherent toxicity. Therefore, the research literature appears to be lacking in medicinal chemistry reports related to this class of compounds. However, despite this notion, the nitroheterocycles have enjoyed a marked renaissance in the last years, particularly, in antimicrobial area. Therefore, an attempt to summarize, within a single review article, the medicinal applications and methods of synthesis has been undertaken.
Export Options
About this article
Cite this article as:
Chuprun S. Sergey , Kantin Grigory and Krasavin Mikhail *, Synthesis and Medicinal Applications of N-Aryl-C-nitroazoles, Mini-Reviews in Medicinal Chemistry 2018; 18(20) . https://dx.doi.org/10.2174/1389557518666180831101841
DOI https://dx.doi.org/10.2174/1389557518666180831101841 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |

- Author Guidelines
- Editorial Policies
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Allegations from Whistleblowers
- Publishing Ethics and Rectitude
- Increase Visibility Of Your Article
- Archiving Policies
- Reviewer Guidelines
- Guest Editor Guidelines
- Board Recruitment Workflow
- Short Guide for New Editors
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Announcements
- Forthcoming Thematic Issues
Related Articles
-
Role of the Blood-Brain Barrier in the Pathogenesis of Alzheimers Disease
Current Alzheimer Research Editorial [Hot Topic: Paracrine Mechanisms, Signaling and Epigenetics in Repairing Damaged Tissue]
Recent Patents on Regenerative Medicine Endophthalmitis
Anti-Infective Agents in Medicinal Chemistry Activated Protein C and Acute Kidney Injury: Selective Targeting of PAR-1
Current Drug Targets The Role of Mesenchymal Stem Cells in Immune Response
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Approaches Used in Immunotherapy for Prostate Cancer
Current Cancer Therapy Reviews New Insights in the Mechanism of Bone Loss in Arthritis
Current Pharmaceutical Design The Neuroscience of Maternal Behaviour
Current Psychiatry Reviews Malignant Hypercalcemia
Current Medicinal Chemistry Patent Selections:
Recent Patents on Anti-Infective Drug Discovery AICD Nuclear Signaling and Its Possible Contribution to Alzheimers Disease
Current Alzheimer Research Synthesis & Characterization of 2-(substituted-phenyl)acetohydrazide Analogs, 1,3,4-oxadiazoles, and 1,2,4-triazine Ring Systems: A Novel Class of Potential Analgesic and Anti-Inflammatory Agents
Letters in Drug Design & Discovery Differential Characteristics of HMGB2 Versus HMGB1 and their Perspectives in Ovary and Prostate Cancer
Current Medicinal Chemistry Airway Epithelium Directed Gene Therapy for Cystic Fibrosis
Medicinal Chemistry Chromosomal Excision of a New Pathogenicity Island Modulates Salmonella Virulence In Vivo
Current Gene Therapy Antibody-Based Targeted Interventions for the Diagnosis and Treatment of Skin Cancers
Anti-Cancer Agents in Medicinal Chemistry Tailored Angiogenesis Inhibition in Cancer Therapy: Respecting the Heart to Improve the Net Outcome
Current Signal Transduction Therapy Lipoprotein(a): Current Perspectives
Current Vascular Pharmacology Targeting TNF-Alpha to Elucidate and Ameliorate Neuroinflammation in Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets Polypharmacy in Cardiovascular Medicine: Problems and Promises!
Cardiovascular & Hematological Agents in Medicinal Chemistry