Abstract
With the rapid development of high-throughput genomic technologies and the accumulation of genome-wide datasets for human disease, it has been shown that using only reductionistic principles has been difficult to capture the complex biological networks and design rational medication. However, the emerging paradigm of “network based methodology” proposes to harness the power of networks to uncover relationships between various data types of interest for drug discovery. Recent advances include networks that encompass relationships between drugs, disease-related genes, therapeutic targets and diseases. It is shown how network techniques can help in the investigation of the mechanism of action of existing drugs, new molecules, or to identify novel disease genes and targets. We review how these different types of network analysis approaches facilitate drug discovery and their associated challenges. Some representative examples are reviewed to show that network analysis is a powerful, integrated, computational and experimental approach to improve the drug discovery process.
Keywords: Drug discovery, target identification, network analysis.
Mini-Reviews in Medicinal Chemistry
Title:Network based Approach to Drug Discovery: A Mini Review
Volume: 15 Issue: 8
Author(s): Peng Li, Yingxue Fu and Yonghua Wang
Affiliation:
Keywords: Drug discovery, target identification, network analysis.
Abstract: With the rapid development of high-throughput genomic technologies and the accumulation of genome-wide datasets for human disease, it has been shown that using only reductionistic principles has been difficult to capture the complex biological networks and design rational medication. However, the emerging paradigm of “network based methodology” proposes to harness the power of networks to uncover relationships between various data types of interest for drug discovery. Recent advances include networks that encompass relationships between drugs, disease-related genes, therapeutic targets and diseases. It is shown how network techniques can help in the investigation of the mechanism of action of existing drugs, new molecules, or to identify novel disease genes and targets. We review how these different types of network analysis approaches facilitate drug discovery and their associated challenges. Some representative examples are reviewed to show that network analysis is a powerful, integrated, computational and experimental approach to improve the drug discovery process.
Export Options
About this article
Cite this article as:
Li Peng, Fu Yingxue and Wang Yonghua, Network based Approach to Drug Discovery: A Mini Review, Mini-Reviews in Medicinal Chemistry 2015; 15 (8) . https://dx.doi.org/10.2174/1389557515666150219143933
DOI https://dx.doi.org/10.2174/1389557515666150219143933 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Current State of Potential Therapeutic Modalities for Glioblastoma Multiforme: A Clinical Review
Current Drug Metabolism Bone Marrow Mesenchymal Stem Cells: Agents of Immunomodulation and Neuroprotection
Current Stem Cell Research & Therapy Cytotoxic Compounds in the Treatment of Castration-Resistant Prostate Cancer
Anti-Cancer Agents in Medicinal Chemistry The Role of Growth Factors in the Prevention and Treatment of Chemotherapy-Induced Peripheral Neurotoxicity
Current Drug Safety Targeting DNA Minor Groove by Hybrid Molecules as Anticancer Agents
Current Medicinal Chemistry Oxidative Stress and Antioxidants in Carcinogenesis and Integrative Therapy of Cancer
Current Pharmaceutical Design Editorial (Thematic Issue: The Predictive Pathology in the Target Therapy Era)
Current Drug Targets NFκB Pathway and microRNA-9 and -21 are Involved in Sensitivity to the Pterocarpanquinone LQB-118 in Different CML Cell Lines
Anti-Cancer Agents in Medicinal Chemistry Monoclonal Antibodies: New Therapeutic Agents for Autoimmune Hemolytic Anemia?
Endocrine, Metabolic & Immune Disorders - Drug Targets Therapeutic Peptide Mimetics Looking for a Turn to Block Aberrant Players of Malignancy
Current Cancer Therapy Reviews Fluorescent Cisplatin Analogues and Cytotoxic Activity
Current Medicinal Chemistry Withdrawal Notice: Electrophoresis as a Tool for Early Cancer Diagnosis
Anti-Cancer Agents in Medicinal Chemistry Unexpected High Levels of Vorinostat when Combined with Vinorelbine in Patients with Advanced Cancer
Current Clinical Pharmacology Heat Shock Protein 90 Inhibitors as Therapeutic Agents
Recent Patents on Anti-Cancer Drug Discovery RUNX2 and Osteosarcoma
Anti-Cancer Agents in Medicinal Chemistry Novel and Emerging Drugs for Rarer Chronic Lymphoid Leukaemias
Current Cancer Drug Targets Laboratory Monitoring of Hematological and Hepatic Parameters in Ambulatory Patients Receiving Alpha-Methyldopa in a Nigerian Tertiary Care Setting
Current Drug Safety What are the Cancer Risks in BRCA Carriers Apart from Those Regarding the Breast and the Ovary?
Current Women`s Health Reviews ChemoImmunoModulation: Immune Regulation by the Antineoplastic Chemotherapeutic Agents
Current Medicinal Chemistry The Medical Use of Wheatgrass: Review of the Gap Between Basic and Clinical Applications
Mini-Reviews in Medicinal Chemistry