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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Synthesis of Unnatural Amino Acids via Microwave-assisted Regio-selective One-pot multi-component Reactions of Sulfamidates

Author(s): Nasir B. R. Baig and Rajender S. Varma

Volume 17, Issue 20, 2013

Page: [2323 - 2331] Pages: 9

DOI: 10.2174/13852728113179990047

Price: $65

Abstract

Synthesis of triazole based unnatural amino acids, triazole bis-amino acids and β-amino triazole has been described via stereo and regio-selective one-pot multi-component reaction of sulfamidates, sodium azide, and alkynes under MW irradiation conditions. The developed method is applicable to a broad substrate scope and has significant potential for the synthesis of triazole modified unnatural amino acids.

Keywords: Sulfamidates, Click chemistry, Unnatural amino acids, Triazole, Microwave.


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