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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

1,3,4-Oxadiazole Derivatives as Potential Biological Agents

Author(s): Juan Sun, Jigar A. Makawana and Hai-Liang Zhu

Volume 13, Issue 12, 2013

Page: [1725 - 1743] Pages: 19

DOI: 10.2174/13895575113139990071

Price: $65


The synthesis of novel compound libraries along with screening is a rapid and effective approach for the discovery of potential chemical agents, and it becomes an important method in pharmaceutical chemistry research. 1,3,4- oxadiazole derivatives as the typical heterocyclic compounds, exhibit a broad spectrum of biological activities and vital leading compounds for the development of chemical drugs. Herein, we focus on the synthesis and screening of novel 1,3,4-oxadiazoles derivatives with antimicrobial, antitumor or antiviral activities during the past decade. In this review, we discussed the synthetic development of 1,3,4-oxadiazoles derivatives, and also the relevant bioactivity and their prospects as the potential chemical drugs.

Keywords: 1, 3, 4-oxadiazole, synthesis, antimicrobial, anticancer, antiviral, bioactivities.

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