Abstract
This mini-review will provide an overview on the recent studies of structure and thermodynamics of RNA aptamers that target drug molecules. These aptamers are studied to provide insight into RNA drug interactions. This interaction is important due to the many roles RNA plays in cell biology.
Keywords: Ribonucleic acid, aptamer, thermodynamics, isothermal titration calorimetry, RNA structure, in vitro, PEG, AUCGCA loop
Mini-Reviews in Medicinal Chemistry
Title:Structure and Thermodynamics of Drug-RNA Aptamer Interactions
Volume: 13 Issue: 4
Author(s): J. B. Da Costa and T. Dieckmann
Affiliation:
Keywords: Ribonucleic acid, aptamer, thermodynamics, isothermal titration calorimetry, RNA structure, in vitro, PEG, AUCGCA loop
Abstract: This mini-review will provide an overview on the recent studies of structure and thermodynamics of RNA aptamers that target drug molecules. These aptamers are studied to provide insight into RNA drug interactions. This interaction is important due to the many roles RNA plays in cell biology.
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Cite this article as:
B. Da Costa J. and Dieckmann T., Structure and Thermodynamics of Drug-RNA Aptamer Interactions, Mini-Reviews in Medicinal Chemistry 2013; 13 (4) . https://dx.doi.org/10.2174/1389557511313040001
DOI https://dx.doi.org/10.2174/1389557511313040001 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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