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Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Synthesis and Preliminary Antihyperlipidaemic Activities Evaluation of Andrographolide Derivatives

Author(s): Bin Wang, Chunlei Tang, Yaodan Han, Ruzhou Guo, Hai Qian, Wenlong Huang

Volume 8, Issue 2, 2012

Page: [293 - 298] Pages: 6

DOI: 10.2174/157340612800493629

Price: $65

Abstract

Recent studies indicated that andrographolide was a potential antihyperlipidaemic therapeutic agent. In the paper, the synthesis of a series of andrographolide derivatives was described and their antihyperlipidaemic activities were evaluated in vivo. As compared with TG, TC, HDL-C and LDL-C concentrations, some of the derivatives exhibited better antihyperlipidaemic effects than positive control atromide. Therein, compound 6i, which was the most potent compound, could serve as a new lead for further development of antihyperlipidaemic agents.

Keywords: andrographolide, antihyperlipidaemic activities, derivatives, synthesis, Cholesterol, hyperlipidemia, Green tea, Artichoke, Guggul, plants


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