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Reviews on Recent Clinical Trials


ISSN (Print): 1574-8871
ISSN (Online): 1876-1038

Ibandronate in Benign Bone Disease

Author(s): Tania Winzenberg and Graeme Jones

Volume 3, Issue 2, 2008

Page: [139 - 149] Pages: 11

DOI: 10.2174/157488708784223862

Price: $65


Ibandronate is a potent bisphosphonate which has been most thoroughly assessed in benign bone disease for use in the management of postmenopausal osteoporosis. Its use in corticosteroid-induced osteoporosis, Pagets disease and uncommon benign bone conditions such as localised transient osteoporosis (or bone marrow oedema syndrome) and sternocostoclavicular hyperostosis has also been explored. Recent randomised controlled trial evidence suggests that intermittent high dosage oral ibandronate may be as efficacious as a daily low dose regime for the treatment of post-menopausal osteoporosis, with only a mild increase in adverse events. Movement towards an extended gap between doses has implications for patient compliance and adherence and thus potential benefits for fracture prevention. This review aims to provide an overview of the evidence from randomised controlled trials in humans for the use of ibandronate in benign bone diseases. This includes a discussion of the development program and dosage regimens for the prevention and treatment of postmenopausal osteoporosis, as well as the use of ibandronate in corticosteroid induced osteoporosis, Pagets disease localised transient osteoporosis and sternoclavicular hyperostosis. Adverse effects and long-term safety data will also be reviewed.

Keywords: bone mineral density, Postmenopausal Osteoporosis, Osteoarthritis, type 1 collagen, Corticosteroid-Induced Osteoporosis, Pagets Disease

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