Abstract
Infectious diseases such as tuberculosis, malaria, the “simple flu” or HIV and HBV, are killing more than 50,000 people a day according to estimations by the World Health Organisation (WHO). Consequently, the development of biologically active agents in general, such as antibiotics and chemotherapeutics, is of great importance. Hand in hand with the understanding of the mechanisms of biological agents, structures carrying sugar moieties have become increasingly important during the last decades. This review will cover the most recent developments in the field of new antibiotics and synthetic agents containing carbohydrates which are active against tuberculosis and malaria. In addition, compounds having antiviral, antibacterial and anticancer properties will be examined. Compounds such as aminoglycosides, iminosugars, carbacycles, nucleosides, and other selected substance classes will be considered.
Keywords: carbohydrates, nucleosides, carbasugars, antibiotics, glycopeptide conjugates, chemotherapeutics
Mini-Reviews in Medicinal Chemistry
Title: Bioactive Carbohydrates and Recently Discovered Analogues as Chemotherapeutics
Volume: 4 Issue: 4
Author(s): Tanja M. Wrodnigg and Friedrich K. (Fitz) Sprenger
Affiliation:
Keywords: carbohydrates, nucleosides, carbasugars, antibiotics, glycopeptide conjugates, chemotherapeutics
Abstract: Infectious diseases such as tuberculosis, malaria, the “simple flu” or HIV and HBV, are killing more than 50,000 people a day according to estimations by the World Health Organisation (WHO). Consequently, the development of biologically active agents in general, such as antibiotics and chemotherapeutics, is of great importance. Hand in hand with the understanding of the mechanisms of biological agents, structures carrying sugar moieties have become increasingly important during the last decades. This review will cover the most recent developments in the field of new antibiotics and synthetic agents containing carbohydrates which are active against tuberculosis and malaria. In addition, compounds having antiviral, antibacterial and anticancer properties will be examined. Compounds such as aminoglycosides, iminosugars, carbacycles, nucleosides, and other selected substance classes will be considered.
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Cite this article as:
Wrodnigg M. Tanja and Sprenger K. (Fitz) Friedrich, Bioactive Carbohydrates and Recently Discovered Analogues as Chemotherapeutics, Mini-Reviews in Medicinal Chemistry 2004; 4 (4) . https://dx.doi.org/10.2174/1389557043403918
DOI https://dx.doi.org/10.2174/1389557043403918 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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