Abstract
Imidazole and benzimidazole systems are presented in a large number of common therapeutics agents. They were widely used in organic and medicinal chemistry, but recently the development of N-oxide derivatives got an improvement from the point of view of its chemical and biological activity. Though we will review recent developments in chemical and biological profiles (as antitumoral, antiparasitic, antiviral and antimicrobial agents) of these heterocycle systems and the corresponding N-oxides.
Keywords: pharmacophore, microwave-assisted chemistry, benzimidazole, solid-phase synthesis, one-pot cyclization, nitroimidazole, chemotherapy
Mini-Reviews in Medicinal Chemistry
Title: Imidazole and Benzimidazole Derivatives as Chemotherapeutic Agents
Volume: 5 Issue: 4
Author(s): Mariana Boiani and Mercedes Gonzalez
Affiliation:
Keywords: pharmacophore, microwave-assisted chemistry, benzimidazole, solid-phase synthesis, one-pot cyclization, nitroimidazole, chemotherapy
Abstract: Imidazole and benzimidazole systems are presented in a large number of common therapeutics agents. They were widely used in organic and medicinal chemistry, but recently the development of N-oxide derivatives got an improvement from the point of view of its chemical and biological activity. Though we will review recent developments in chemical and biological profiles (as antitumoral, antiparasitic, antiviral and antimicrobial agents) of these heterocycle systems and the corresponding N-oxides.
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Cite this article as:
Boiani Mariana and Gonzalez Mercedes, Imidazole and Benzimidazole Derivatives as Chemotherapeutic Agents, Mini-Reviews in Medicinal Chemistry 2005; 5 (4) . https://dx.doi.org/10.2174/1389557053544047
DOI https://dx.doi.org/10.2174/1389557053544047 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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