Abstract
2,3-Didehydro- and 2,3-dideoxynucleosides are both potent antiviral agents. In particular, they are Nucleoside Reverse Transcriptase Inhibitors and hence active against HIV, the ethiological agent of AIDS. They are also intermediates for the synthesis of antiviral 2,3-dideoxynucleosides. Various aspects of synthetic routes to 2,3-unsaturated nucleosides are reviewed with examples being chosen from work published between 1966 and 2003.
Keywords: reverse transcriptase (RT), Halogenoacetate, bromomesylate, deprotection, Eastwood reaction
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
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