Abstract
The application of organosilicon chemistry is a strategy to develop best in class drugs applied to targets that have been validated as tractable and drug-able. Silicon switches of known drugs have been synthesised and evaluated in biological assay systems then compared to their marketed all-carbon counterparts. Recent examples include the silicon switches of drugs haloperidol, fexofenadine, bexarotene and venlafaxine.
Keywords: Organosilicon chemistry, silicon switch, marketed drugs, validated targets
Mini-Reviews in Medicinal Chemistry
Title: Silicon Switches of Marketed Drugs
Volume: 6 Issue: 10
Author(s): P. K. Pooni and G. A. Showell
Affiliation:
Keywords: Organosilicon chemistry, silicon switch, marketed drugs, validated targets
Abstract: The application of organosilicon chemistry is a strategy to develop best in class drugs applied to targets that have been validated as tractable and drug-able. Silicon switches of known drugs have been synthesised and evaluated in biological assay systems then compared to their marketed all-carbon counterparts. Recent examples include the silicon switches of drugs haloperidol, fexofenadine, bexarotene and venlafaxine.
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Cite this article as:
K. Pooni P. and A. Showell G., Silicon Switches of Marketed Drugs, Mini-Reviews in Medicinal Chemistry 2006; 6 (10) . https://dx.doi.org/10.2174/138955706778560120
DOI https://dx.doi.org/10.2174/138955706778560120 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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