Abstract
In metabolomics studies there is a clear increase of data. This indicates the necessity of both having a battery of suitable analysis methods and validation procedures able to handle large amounts of data. In this review, an overview of the metabolomics data processing pipeline is presented. A selection of recently developed and most cited data processing methods is discussed. In addition, commonly used chemometric and machine learning analysis methods as well as validation approaches are described.
Keywords: Multivariate data analysis, data processing, chemometrics, metabolomics, statistical validation, validation procedures, chemometric and machine learning analysis, NMR, downstream data analysis, Filtration, non-linear regression method
Current Pharmaceutical Biotechnology
Title: From Data Processing to Multivariate Validation - Essential Steps in Extracting Interpretable Information from Metabolomics Data
Volume: 12 Issue: 7
Author(s): Mattias Eliasson, Stefan Rannar and Johan Trygg
Affiliation:
Keywords: Multivariate data analysis, data processing, chemometrics, metabolomics, statistical validation, validation procedures, chemometric and machine learning analysis, NMR, downstream data analysis, Filtration, non-linear regression method
Abstract: In metabolomics studies there is a clear increase of data. This indicates the necessity of both having a battery of suitable analysis methods and validation procedures able to handle large amounts of data. In this review, an overview of the metabolomics data processing pipeline is presented. A selection of recently developed and most cited data processing methods is discussed. In addition, commonly used chemometric and machine learning analysis methods as well as validation approaches are described.
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Cite this article as:
Eliasson Mattias, Rannar Stefan and Trygg Johan, From Data Processing to Multivariate Validation - Essential Steps in Extracting Interpretable Information from Metabolomics Data, Current Pharmaceutical Biotechnology 2011; 12 (7) . https://dx.doi.org/10.2174/138920111795909041
DOI https://dx.doi.org/10.2174/138920111795909041 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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