Abstract
Introduction: Intranasal drug administration is a non-invasive method of bypassing the blood—brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This method also delivers those drugs that do not cross the BBB to the central nervous system (CNS) thus eliminating the need for systemic delivery, and subsequently reducing the unwanted systemic side effects. Delivery from the nose- to-brain occurs within minutes along both the olfactory and trigeminal neural pathways. Materials and Methods: Rat model was developed to determine existence of neural and non neural pathways after nasal delivery in rats. For the study mucoadhesive nanoparticles were prepared by ionic crosslinking method and the study was investigated using intranasal administration of Tc99m labeled chitosan nanoparticulate formulation in dead and alive rats. Result: The result showed a significant increase of 4.4 times radiolabeled drug concentration in the brain of live rats as compared to the radiolabeled drug concentration in the dead rats (p < 0.01). Conclusion This experimental rat model provides a proof for existence of neural and non-neural pathway for nose to brain using a novel formulation for crossing BBB which is of importance in finding a solution for neurodegenerative disorders.
Keywords: Olfactory, trigeminal, radiolabeled, nose-to-brain, nasal drug delivery, neural, non-neural
Current Nanoscience
Title: Reflection on Existence of Neural and Non-Neural Pathway for Nose- to- Brain Using a Novel Formulation of an Anticholinesterase Piperidine Derivative
Volume: 6 Issue: 3
Author(s): Javed Ali, Mushir Ali, Sanjula Baboota, Rashid Ali, Gaurav Mittal, Aseem Bhatnagar and Bhavna
Affiliation:
Keywords: Olfactory, trigeminal, radiolabeled, nose-to-brain, nasal drug delivery, neural, non-neural
Abstract: Introduction: Intranasal drug administration is a non-invasive method of bypassing the blood—brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This method also delivers those drugs that do not cross the BBB to the central nervous system (CNS) thus eliminating the need for systemic delivery, and subsequently reducing the unwanted systemic side effects. Delivery from the nose- to-brain occurs within minutes along both the olfactory and trigeminal neural pathways. Materials and Methods: Rat model was developed to determine existence of neural and non neural pathways after nasal delivery in rats. For the study mucoadhesive nanoparticles were prepared by ionic crosslinking method and the study was investigated using intranasal administration of Tc99m labeled chitosan nanoparticulate formulation in dead and alive rats. Result: The result showed a significant increase of 4.4 times radiolabeled drug concentration in the brain of live rats as compared to the radiolabeled drug concentration in the dead rats (p < 0.01). Conclusion This experimental rat model provides a proof for existence of neural and non-neural pathway for nose to brain using a novel formulation for crossing BBB which is of importance in finding a solution for neurodegenerative disorders.
Export Options
About this article
Cite this article as:
Ali Javed, Ali Mushir, Baboota Sanjula, Ali Rashid, Mittal Gaurav, Bhatnagar Aseem and Bhavna , Reflection on Existence of Neural and Non-Neural Pathway for Nose- to- Brain Using a Novel Formulation of an Anticholinesterase Piperidine Derivative, Current Nanoscience 2010; 6 (3) . https://dx.doi.org/10.2174/157341310791171135
DOI https://dx.doi.org/10.2174/157341310791171135 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Low Grade Inflammation as a Common Pathogenetic Denominator in Age-Related Diseases: Novel Drug Targets for Anti-Ageing Strategies and Successful Ageing Achievement
Current Pharmaceutical Design Recent Advances in Progressive Supranuclear Palsy: A Review
Current Alzheimer Research Flavonoids in Neurodegeneration: Limitations and Strategies to Cross CNS Barriers
Current Medicinal Chemistry Astrocytes: From the Physiology to the Disease
Current Alzheimer Research Treatment Strategies Against Diabetic Foot Ulcer: Success so Far and the Road Ahead
Current Diabetes Reviews The Use of Chronobiotics in the Resynchronization of the Sleep/Wake Cycle. Therapeutical Application in the Early Phases of Alzheimer's Disease
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Histone Deacetylase Inhibitors and Neurodegenerative Disorders: Holding the Promise
Current Pharmaceutical Design Multi-Target Compounds Acting in the Central Nervous System Designed From Natural Products
Current Medicinal Chemistry C-terminus of Hsp70 Interacting Protein (CHIP) and Neurodegeneration: Lessons from the Bench and Bedside
Current Neuropharmacology Efficacy of Ropinirole-Loaded PLGA Microspheres for the Reversion of Rotenone- Induced Parkinsonism
Current Pharmaceutical Design A New Hypothesis of Pathogenesis Based on the Divorce between Mitochondria and their Host Cells: Possible Relevance for Alzheimers Disease
Current Alzheimer Research In Silico Analysis of Green Tea Polyphenols as Inhibitors of AChE and BChE Enzymes in Alzheimer’s Disease Treatment
CNS & Neurological Disorders - Drug Targets Therapeutic Potential of Vasoactive Intestinal Peptide and its Receptors in Neurological Disorders
CNS & Neurological Disorders - Drug Targets Cross-Talk Between NO Synthase Isoforms in Neuro-Inflammation: Possible Implications in HIV-Associated Neurocognitive Disorders
Current Medicinal Chemistry The Molecular Basis of Conantokin Antagonism of NMDA Receptor Function
Current Drug Targets Targeting Macrophage for the Treatment of Amyotrophic Lateral Sclerosis
CNS & Neurological Disorders - Drug Targets Is There Any Scientific Basis of Hawan to be Used in the Alzheimer’s Disease Prevention/Cure?
Current Traditional Medicine Molecular Targets of Tannic Acid in Alzheimer's Disease
Current Alzheimer Research Natural Products Based Ayurvedic Formulations: Chemical Cons tituents and Treatment in Neurodegenerative Disordersǂ
Mini-Reviews in Organic Chemistry The Glutamate Hypothesis in ALS: Pathophysiology and Drug Development
Current Medicinal Chemistry