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Pharmaceutical Nanotechnology

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ISSN (Print): 2211-7385
ISSN (Online): 2211-7393

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Review Article

Emphasis on Nanostructured Lipid Carriers in the Ocular Delivery of Antibiotics

Author(s): Chandra Pratap Singh, Pankaj Kumar Rai, Manish Kumar*, Varsha Tiwari, Abhishek Tiwari, Ajay Sharma and Kamini Sharma

Volume 12, Issue 2, 2024

Published on: 25 August, 2023

Page: [126 - 142] Pages: 17

DOI: 10.2174/2211738511666230727102213

Price: $65

Abstract

Background: Drug distribution to the eye is still tricky because of the eye’s intricate structure. Systemic delivery, as opposed to more traditional methods like eye drops and ointments, is more effective but higher doses can be harmful.

Objective: The use of solid lipid nanoparticles (SLNPs) as a method of drug delivery has been the subject of research since the 1990s. Since SLNPs are derived from naturally occurring lipids, they pose no health risks to the user. To raise the eye's absorption of hydrophilic and lipophilic drugs, SLNs can promote corneal absorption and improve the ocular bioavailability of SLNPs.

Methods: To address problems related to ocular drug delivery, many forms of nano formulation were developed. Some of the methods developed are, emulsification and ultra-sonication, high-speed stirring and ultra-sonication, thin layer hydration, adapted melt-emulsification, and ultrasonication techniques, hot o/w micro-emulsion techniques, etc.

Results: Nanostructured lipid carriers are described in this review in terms of their ocular penetration mechanism, structural characteristic, manufacturing process, characterization, and advantages over other nanocarriers.

Conclusion: Recent developments in ocular formulations with nanostructured bases, such as surfacemodified attempts have been made to increase ocular bioavailability in both the anterior and posterior chambers by incorporating cationic chemicals into a wide variety of polymeric systems.

Keywords: Pre-corneal retention, mucoadhesion, lipid nanoparticles, ocular medication delivery, transcorneal penetration, drug distribution.

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