Histological and in vivo Study on Novel Polyelectrolyte Complex Vildagliptin Loaded Microbeads in Streptozotocin-induced Rat Model

Title:Histological and in vivo Study on Novel Polyelectrolyte Complex Vildagliptin Loaded Microbeads in Streptozotocin-induced Rat Model

Volume: 19

Author(s): Ritesh Kumar Tiwari*, Lalit Singh, Mukesh Kr. Tiwari and Rajat Yadav

Affiliation:

• Shri Ram Murti Smarak College Engineering & Technology (Pharmacy), Bareilly, India

Keywords: Polyelectrolyte complex microbeads, Histopathology, Streptozotocin induced diabetes, Biochemical Parameters., Vildagliptin, lipid profiles

Abstract: Background: This study aimed to investigate the effect of vildagliptin-containing polyelectrolyte complex microbeads formulation in a streptozotocin-induced diabetic rat model.

Objective: Vildagliptin-containing polyelectrolyte complex microbeads were given to diabetic rats at a dose of 2.5 mg/kg body weight in order to study their antidiabetic, hypolipidemic histopathological conditions.

Methods: A portable glucometer was used to measure the blood glucose level using a reagent strip. After vildagliptin formulation was administered orally to healthy streptozotocin-induced rats, other parameters, such as liver profile and total lipid levels, were assessed.

Result: Vildagliptin-containing polyelectrolyte complex microbeads were found to significantly decrease high glucose levels and improve kidney, liver, and hyperlipidaemia caused due to diabetes. Vildagliptin-containing polyelectrolyte complex microbeads also had a favourable impact on alterations in the liver and pancreatic histopathology in diabetes caused by streptozotocin.

Conclusion: Vildagliptin-containing polyelectrolyte complex microbeads have the ability to enhance a variety of lipid profiles, including those related to body weight, liver, kidney, and total lipid profiles. Vildagliptin-containing polyelectrolyte complex microbeads have also been found to be effective in preventing the histological alterations in the liver and pancreas occurred in streptozotocin-induced diabetes.

Cite this article as:

Kumar Tiwari Ritesh*, Singh Lalit, Kr. Tiwari Mukesh and Yadav Rajat, Histological and in vivo Study on Novel Polyelectrolyte Complex Vildagliptin Loaded Microbeads in Streptozotocin-induced Rat Model, Current Diabetes Reviews 2023; 19 () : e190423216030 . https://dx.doi.org/10.2174/1573399819666230419091309