Title:Alzheimer’s Disease And Type 2 Diabetes: Exploring The Association To Obesity And Tyrosine Hydroxylase
VOLUME: 11 ISSUE: 4
Author(s):Medha Priyadarshini, Mohammad A. Kamal, Nigel H. Greig, Marcella Realef, Adel M. Abuzenadah, Adeel G.A. Chaudhary and Ghazi A. Damanhouri
Affiliation:Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, UP, India.
Keywords:Type 2 diabetes mellitus, Alzheimer’s disease, Parkinson’s disease, neurodegeneration, tyrosine hydroxylase,
dementia, obesity, insulin resistance, metabolic syndrome, neuroinflammation.
Abstract:Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM) are two debilitating health disorders afflicting
millions worldwide. Recent research has revealed similarities between AD and T2DM. Both these protein conformational
disorders are associated with obesity, insulin resistance, inflammation and endoplasmic reticulum stress, en-route
initiation and/or stage aggravation. In this mini review we have tried to summarize studies describing obesity, insulin
resistance and glucocorticoid imbalance as common patho-mechanisms in T2DM and AD. A reduction in tyrosine
hydroxylase (TH) in the brain has been found to occur in Parkinson’s disease (PD). AD, T2DM and PD share common
risk factors like depression. Thus, whether TH is involved in the ‘state of cognitive depression’ that is the hallmark of AD
and often accompanies PD and T2DM is also explored.
