Passion fruit (Passiflora edulis Sims f. flavicarpa) is popularly known for its sedative and calming
properties and is consumed as a fresh fruit or as a juice. The clinical observation of blood incoagulability associated
with excessive consumption of passion fruit juice, in a patient treated with warfarin, prompted the current
study to investigate in vitro the presence of blood clotting inhibitors in Passiflora edulis Sims f. flavicarpa extract.
After purification process, two compounds of distinct molecular weight and inhibitory action were better characterized.
One is a trypsin inhibitor similar to inhibitors from Bowman-Birk family, named PeTI-I12, and other is a compound active
in coagulation that prolongs aPTT and PT, but does not change TT. The aim of this study is to provide evidence
that passion fruit extract’s components play a role on hemostasis and therefore may be relevant in the handling
of patients treated with anticoagulants or suffering hemorrhagic diseases.
Keywords: aPTT, blood coagulation, Bowman-Birk inhibitor, Passiflora edulis, passion fruit, Passifloraceae, trypsin inhibitor,
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Published on: 01 April, 2012
Page: [501 - 508]